临床儿科杂志
臨床兒科雜誌
림상인과잡지
Journal of Clinical Pediatrics
2015年
10期
903-906
,共4页
坏死性小肠结肠炎%肠源性败血症%新生儿
壞死性小腸結腸炎%腸源性敗血癥%新生兒
배사성소장결장염%장원성패혈증%신생인
necrotizing enterocolitis%gut-origin sepsis%neonate
新生儿坏死性小肠结肠炎（NEC）是新生儿时期严重的胃肠道疾病之一，病死率较高。研究表明NEC可并发肠源性败血症，且与高病死率有关，故积极探寻NEC导致败血症发生的相关因素及防治措施，对改善NEC患儿预后有重要意义。近年来研究表明,NEC导致败血症的主要危险因素包括早产与低出生体质量、需要长时间静脉营养、抗生素使用时间过长；主要的病原菌为革兰阴性杆菌；通过补充益生菌、谷氨酰胺、乳铁蛋白能够降低NEC发病率及严重程度，可能有助于进一步减少肠源性败血症的风险。
新生兒壞死性小腸結腸炎（NEC）是新生兒時期嚴重的胃腸道疾病之一，病死率較高。研究錶明NEC可併髮腸源性敗血癥，且與高病死率有關，故積極探尋NEC導緻敗血癥髮生的相關因素及防治措施，對改善NEC患兒預後有重要意義。近年來研究錶明,NEC導緻敗血癥的主要危險因素包括早產與低齣生體質量、需要長時間靜脈營養、抗生素使用時間過長；主要的病原菌為革蘭陰性桿菌；通過補充益生菌、穀氨酰胺、乳鐵蛋白能夠降低NEC髮病率及嚴重程度，可能有助于進一步減少腸源性敗血癥的風險。
신생인배사성소장결장염（NEC）시신생인시기엄중적위장도질병지일，병사솔교고。연구표명NEC가병발장원성패혈증，차여고병사솔유관，고적겁탐심NEC도치패혈증발생적상관인소급방치조시，대개선NEC환인예후유중요의의。근년래연구표명,NEC도치패혈증적주요위험인소포괄조산여저출생체질량、수요장시간정맥영양、항생소사용시간과장；주요적병원균위혁란음성간균；통과보충익생균、곡안선알、유철단백능구강저NEC발병솔급엄중정도，가능유조우진일보감소장원성패혈증적풍험。
Necrotizing enterocolitis (NEC) is one of the severe gastrointestinal emergencies with high mortality in neo-natal period. Studies suggested that sepsis from NEC were associated with higher mortality in NEC. Therefore, it is important to explore the related factors and prevention measures of NEC and improve the prognosis of children with NEC. In recent years, studies have shown that the risk factors of sepsis in NEC included prematurity, low birth weight, long time of total parenteral nutrition supports and long duration of antibiotic exposure. The main pathogen of sepsis was gram-negative bacilli. Probiotics, glutamine and lactoferrin supplementation may reduce the incidence and severity of NEC, and may help further reduce the risk of gut-derived sepsis.
