中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
10期
2566-2568
,共3页
甘梅富%徐铖%张玲娜%翁寿向%周晶晶
甘梅富%徐鋮%張玲娜%翁壽嚮%週晶晶
감매부%서성%장령나%옹수향%주정정
结直肠癌%星形细胞上调基因-1%程序性细胞死亡因子4
結直腸癌%星形細胞上調基因-1%程序性細胞死亡因子4
결직장암%성형세포상조기인-1%정서성세포사망인자4
Colorectal carcinoma%Astrocyte elevated gene-1%Programmed cell death 4
目的 探讨星形细胞上调基因-1(AEG-1)、程序性细胞死亡因子4(PDCD4)在结直肠癌组织中的表达水平及其与结直肠癌临床病理特征的关系.方法 采用免疫组织化学法检测AEG-1和PDCD4在89例原发性大肠癌组织及相应癌旁组织中的表达水平,分析AEG-1和PDCD4的表达水平与结直肠癌临床病理学之间的关系.结果 AEG-1在结直肠癌癌组织中表达率明显高于癌旁组织(69.66％比14.61％,P＜0.01),AEG-1表达水平与结直肠癌组织学分级、浸润深度、TNM分期和淋巴结转移明显相关(P＜0.05);PDCD4在结直肠癌癌组织中表达率明显低于癌旁组织(31.46％比84.27％,P＜0.01),PDCD4表达水平与结直肠癌TNM分期、淋巴结转移明显相关(P＜0.05).结论 AEG-1高表达及PDCD4低表达在结直肠癌的发生发展及浸润转移中具有-定的作用.
目的 探討星形細胞上調基因-1(AEG-1)、程序性細胞死亡因子4(PDCD4)在結直腸癌組織中的錶達水平及其與結直腸癌臨床病理特徵的關繫.方法 採用免疫組織化學法檢測AEG-1和PDCD4在89例原髮性大腸癌組織及相應癌徬組織中的錶達水平,分析AEG-1和PDCD4的錶達水平與結直腸癌臨床病理學之間的關繫.結果 AEG-1在結直腸癌癌組織中錶達率明顯高于癌徬組織(69.66％比14.61％,P＜0.01),AEG-1錶達水平與結直腸癌組織學分級、浸潤深度、TNM分期和淋巴結轉移明顯相關(P＜0.05);PDCD4在結直腸癌癌組織中錶達率明顯低于癌徬組織(31.46％比84.27％,P＜0.01),PDCD4錶達水平與結直腸癌TNM分期、淋巴結轉移明顯相關(P＜0.05).結論 AEG-1高錶達及PDCD4低錶達在結直腸癌的髮生髮展及浸潤轉移中具有-定的作用.
목적 탐토성형세포상조기인-1(AEG-1)、정서성세포사망인자4(PDCD4)재결직장암조직중적표체수평급기여결직장암림상병리특정적관계.방법 채용면역조직화학법검측AEG-1화PDCD4재89례원발성대장암조직급상응암방조직중적표체수평,분석AEG-1화PDCD4적표체수평여결직장암림상병이학지간적관계.결과 AEG-1재결직장암암조직중표체솔명현고우암방조직(69.66％비14.61％,P＜0.01),AEG-1표체수평여결직장암조직학분급、침윤심도、TNM분기화림파결전이명현상관(P＜0.05);PDCD4재결직장암암조직중표체솔명현저우암방조직(31.46％비84.27％,P＜0.01),PDCD4표체수평여결직장암TNM분기、림파결전이명현상관(P＜0.05).결론 AEG-1고표체급PDCD4저표체재결직장암적발생발전급침윤전이중구유-정적작용.
Objective To explore the expression of astrocyte elevated gene-1 (AEG-1) and programmed cell death 4 (PDCD4) and theicorrelation with clinicopathological featureof colorectal carcinoma.MethodThe immunohistochemical method waused to detecthe expression of AEG-1 and PDCD4 in 89 caseof colorectal carcinomtissueand non-cancerouadjacencolorectal tissues.The expression of AEG-1 and PDCD4 in colorectal carcinomtissueand theirelationship with clinicopathological featurewere analyzed.ResultThe expression rate of AEG-1 in colorectal carcinomtissuewahighethan thain non-cancerouadjacencolorectal tissue(69.66％ vs.14.61％ ,P ＜0.01).The expression of AEG-1 warelated colorectal carcinomto histology grade, invasion depth, TNM stage and lymph node metastasis.The expression rate of PDCD4 in colorectal carcinomtissuewalowethan thain non-cancerouadjacencolorectal tissue(31.46％ vs.84.27％ ,P ＜0.01).The expression of PDCD4 warelated colorectal carcinomto TNM stage and lymph node metastasi(P ＜ 0.05).Conclusion There ihigh expression of AEG-1 and low expression of PDCD4 in colorectal carcinoma.Simultaneoudetection of AEG-1 and PDCD4 mighbe helpful foevaluating the malignance and predicting the metastatipotential of colorectal carcinoma.
