CAJ | 학술논문

Objective:To investigate the effects of standardized dichloromethane(DCM) extract ofCosinium fenestratum(C. fenestratum) stem bark on liver and kidney function parameters in streptozotocin (STZ)-induced diabetic rats.Methods:Standardization of the extract was performed through high performance liquid chromatography(HPLC) using berberine(BE) as marker compound.The standardizedC. fenestratum stem bark extract(SCFE) was administered orally at a dose of100 mg/kg toSTZ-induced diabetic rats for15 d.Results:The quantity ofBE in the extract was2.09% w/w.Blood glucose levels, blood urea nitrogen(BUN), alkaline phosphatase(ALP) and creatinine were significantly(P<0.05) elevated inSTZ-induced diabetic rats as compared to normal control groups.Treatment of diabetic rats with the extract significantly(P<0.05) reduced,ALP, creatinine, andBUN levels as compared to the diabetic control group.The total white blood cells(WBC) count was reduced in diabetic rats.Treatment of diabetic rats withSCFE significantly(P<0.05) increased the totalWBC count as compared to the values of diabetic control rats.Conclusion:The observations of the present study show that extract of C. fenestratum stem bark has hepato-renal protective effect inSTZ-induced diabetic rats.