中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
Chinese Journal of Experimental Surgery
2015年
10期
2583-2585
,共3页
曹强%杨扬%许瑞彬%刘延风
曹彊%楊颺%許瑞彬%劉延風
조강%양양%허서빈%류연풍
严重肺挫伤%乌司他丁%高迁移率族蛋白1%肿瘤坏死因子-α%白细胞介素-6%预后
嚴重肺挫傷%烏司他丁%高遷移率族蛋白1%腫瘤壞死因子-α%白細胞介素-6%預後
엄중폐좌상%오사타정%고천이솔족단백1%종류배사인자-α%백세포개소-6%예후
Lung contusion%Ulinastatin%High mobility group box-1%Tumor necrosis factor-α%Interleukin-6%Prognosis
目的 观察乌司他丁对严重肺挫伤患者高迁移率族蛋白1(HMGB1)及全身炎症水平的影响,探讨其对严重肺挫伤患者的治疗作用.方法 纳入严重肺挫伤患者127例,按照随机数字表法分为乌司他丁组(69例)和对照组(58例),分别检测入组后第1、4、7天HMGB1、肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6的表达水平,以及氧合指数、机械通气时间、ICU停留时间、28d死亡率等预后指标.结果 乌司他丁组第1、4、7天HMGB1水平显著低于对照组[(7.81 ±1.67) ng/L比(9.52±1.59) ng/L;(6.74±2.15)ng/L比(8.22±2.47) ng/L;(5.32±1.73) ng/L比(7.56±2.08) ng/L,P＜0.05],乌司他丁组第1、4、7天TNF-α和IL-6的表达水平也低于对照组(P＜0.05);乌司他丁组第1、4、7天氧合指数均显著高于对照组[(291.3±33.7) mmHg比(275.1±38.8) mmHg;(366.8 ±35.1) mmHg比(292.1±64.8) mmHg;(414.6±43.2) mmHg比(335.4 ±53.4) mmHg,P＜0.05],机械通气时间、ICU停留时间、28 d死亡率等指标均低于对照组[(35.7±3.8)h比(42.5±4.3)h;(4.8±1.5)d比(6.5±1.9)d;12.1％比5.8％,P＜0.05,1 mmHg=0.133 kPa].结论 乌司他丁通过抑制HMGB1及其下游炎性因子表达水平达到改善严重肺挫伤患者预后的治疗效果.
目的 觀察烏司他丁對嚴重肺挫傷患者高遷移率族蛋白1(HMGB1)及全身炎癥水平的影響,探討其對嚴重肺挫傷患者的治療作用.方法 納入嚴重肺挫傷患者127例,按照隨機數字錶法分為烏司他丁組(69例)和對照組(58例),分彆檢測入組後第1、4、7天HMGB1、腫瘤壞死因子(TNF)-α和白細胞介素(IL)-6的錶達水平,以及氧閤指數、機械通氣時間、ICU停留時間、28d死亡率等預後指標.結果 烏司他丁組第1、4、7天HMGB1水平顯著低于對照組[(7.81 ±1.67) ng/L比(9.52±1.59) ng/L;(6.74±2.15)ng/L比(8.22±2.47) ng/L;(5.32±1.73) ng/L比(7.56±2.08) ng/L,P＜0.05],烏司他丁組第1、4、7天TNF-α和IL-6的錶達水平也低于對照組(P＜0.05);烏司他丁組第1、4、7天氧閤指數均顯著高于對照組[(291.3±33.7) mmHg比(275.1±38.8) mmHg;(366.8 ±35.1) mmHg比(292.1±64.8) mmHg;(414.6±43.2) mmHg比(335.4 ±53.4) mmHg,P＜0.05],機械通氣時間、ICU停留時間、28 d死亡率等指標均低于對照組[(35.7±3.8)h比(42.5±4.3)h;(4.8±1.5)d比(6.5±1.9)d;12.1％比5.8％,P＜0.05,1 mmHg=0.133 kPa].結論 烏司他丁通過抑製HMGB1及其下遊炎性因子錶達水平達到改善嚴重肺挫傷患者預後的治療效果.
목적 관찰오사타정대엄중폐좌상환자고천이솔족단백1(HMGB1)급전신염증수평적영향,탐토기대엄중폐좌상환자적치료작용.방법 납입엄중폐좌상환자127례,안조수궤수자표법분위오사타정조(69례)화대조조(58례),분별검측입조후제1、4、7천HMGB1、종류배사인자(TNF)-α화백세포개소(IL)-6적표체수평,이급양합지수、궤계통기시간、ICU정류시간、28d사망솔등예후지표.결과 오사타정조제1、4、7천HMGB1수평현저저우대조조[(7.81 ±1.67) ng/L비(9.52±1.59) ng/L;(6.74±2.15)ng/L비(8.22±2.47) ng/L;(5.32±1.73) ng/L비(7.56±2.08) ng/L,P＜0.05],오사타정조제1、4、7천TNF-α화IL-6적표체수평야저우대조조(P＜0.05);오사타정조제1、4、7천양합지수균현저고우대조조[(291.3±33.7) mmHg비(275.1±38.8) mmHg;(366.8 ±35.1) mmHg비(292.1±64.8) mmHg;(414.6±43.2) mmHg비(335.4 ±53.4) mmHg,P＜0.05],궤계통기시간、ICU정류시간、28 d사망솔등지표균저우대조조[(35.7±3.8)h비(42.5±4.3)h;(4.8±1.5)d비(6.5±1.9)d;12.1％비5.8％,P＜0.05,1 mmHg=0.133 kPa].결론 오사타정통과억제HMGB1급기하유염성인자표체수평체도개선엄중폐좌상환자예후적치료효과.
0bjective The aim of the presenstudy wato investigate the effecof ulinastatin to high mobility group protein B1 (HMGB1), inflammtory mediatorand prognosiin severe lung contusion patients.MethodTotal 127 severe lung contusion patientwere randomly divided into ulinastatin and control group.Serum HMGB1, tumonecrosifactor-α (TNF-α), interleukin-6 (IL-6), oxygenation index, mechanical ventilation time, icu length of stay, and 28-day mortality were compared between ulinastatin and control group athe first, fourth and seventh day aftetreatmenbeginning.ResultSerum HMGB1 in ulinastatin group were lowethan control gourp a1, 4 and 7 day[(7.81 ± 1.67) ng/L vs.(9.52±1.59) ng/L;(6.74 ±2.15)ng/Lvs.(8.22±2.47) ng/L;(5.32±1.73) ng/L vs.(7.56± 2.08) ng/L,P ＜ 0.05].TNF-α and IL-6 were also reduced by ulinastatin athe 1,4, 7 day than control group (P ＜ 0.05).More over, mechanical ventilation time, icu length of stay , and 28-day mortality were lowein ulinastatin group than control group[(35.7 ± 3.8) h vs.(42.5 ± 4.3) h;(4.8 ± 1.5) d vs.(6.5 ± 1.9) d;12.1％ vs.5.8％ ,P ＜0.05].Oxygenation index waimproved in hypothermigroup than control group [(291.3 ±33.7) mmHg vs.(275.1 ±38.8) mmHg;(366.8 ±35.1) mmHg vs.(292.1 ±64.8) mmHg;(414.6 ±43.2) mmHg vs.(335.4 ±53.4) mmHg,P＜0.05, 1 mmHg=0.133 kPa].Condusion Ulinastatin improved prognosiin evere lung contusion patientby reduced HMGB1 and inflammatory mediatorlevels.
