中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
20期
3061-3063,3064
,共4页
脑梗死%醒脑静注射液%神经功能%金属蛋白酶 9%一氧化氮%一氧化氮合酶
腦梗死%醒腦靜註射液%神經功能%金屬蛋白酶 9%一氧化氮%一氧化氮閤酶
뇌경사%성뇌정주사액%신경공능%금속단백매 9%일양화담%일양화담합매
Brain Infarction%Xingnaojing injection%Nerve function%Matrix metalloproteinase 9%Nitric oxide%Nitric oxide synthase
目的：研究醒脑静注射液辅助治疗急性脑梗死的疗效及对患者血清基质金属蛋白酶9（MMP9）、一氧化氮（NO）及一氧化氮合酶（NOS）的影响。方法选择急性脑梗死患者112例作为研究对象，采用数字表法随机分成两组，各56例。对照组接受急性脑梗死的常规治疗。观察组在常规治疗的基础上静脉滴注醒脑静注射液。比较治疗前后两组患者 NIHSS 评分、运动功能评分和感觉功能评分的变化，观察治疗前后两组患者血清 MMP-9、NOS、NO 水平的变化。结果观察组总有效率（82．14％）高于对照组（64.29％），差异有统计学意义（χ2＝4．553，P ＜0．05）。治疗后，观察组 NIHSS 评分均低于对照组，差异均有统计学意义（t ＝5．082、5．522、6．253，均 P ＜0．01）。治疗3周，观察组运动功能评分（69．54±17．82）分、感觉功能评分（30．58±7．94）分，均高于对照组运动功能评分（52．93±14．66）分、感觉功能评分（23．08±6．31）分，差异均有统计学意义（t ＝5．387、5．534，均 P ＜0．01）。治疗后，观察组血清 MMP-9、NOS、NO 水平均低于对照组，差异均有统计学意义（均 P ＜0．01）。结论醒脑静注射液辅助治疗急性脑梗死疗效显著，能够促进患者神经功能的恢复，改善运动功能和感觉功能，并通过调节 MMP-9、NOS、NO 水平起到保护神经血管的作用。
目的：研究醒腦靜註射液輔助治療急性腦梗死的療效及對患者血清基質金屬蛋白酶9（MMP9）、一氧化氮（NO）及一氧化氮閤酶（NOS）的影響。方法選擇急性腦梗死患者112例作為研究對象，採用數字錶法隨機分成兩組，各56例。對照組接受急性腦梗死的常規治療。觀察組在常規治療的基礎上靜脈滴註醒腦靜註射液。比較治療前後兩組患者 NIHSS 評分、運動功能評分和感覺功能評分的變化，觀察治療前後兩組患者血清 MMP-9、NOS、NO 水平的變化。結果觀察組總有效率（82．14％）高于對照組（64.29％），差異有統計學意義（χ2＝4．553，P ＜0．05）。治療後，觀察組 NIHSS 評分均低于對照組，差異均有統計學意義（t ＝5．082、5．522、6．253，均 P ＜0．01）。治療3週，觀察組運動功能評分（69．54±17．82）分、感覺功能評分（30．58±7．94）分，均高于對照組運動功能評分（52．93±14．66）分、感覺功能評分（23．08±6．31）分，差異均有統計學意義（t ＝5．387、5．534，均 P ＜0．01）。治療後，觀察組血清 MMP-9、NOS、NO 水平均低于對照組，差異均有統計學意義（均 P ＜0．01）。結論醒腦靜註射液輔助治療急性腦梗死療效顯著，能夠促進患者神經功能的恢複，改善運動功能和感覺功能，併通過調節 MMP-9、NOS、NO 水平起到保護神經血管的作用。
목적：연구성뇌정주사액보조치료급성뇌경사적료효급대환자혈청기질금속단백매9（MMP9）、일양화담（NO）급일양화담합매（NOS）적영향。방법선택급성뇌경사환자112례작위연구대상，채용수자표법수궤분성량조，각56례。대조조접수급성뇌경사적상규치료。관찰조재상규치료적기출상정맥적주성뇌정주사액。비교치료전후량조환자 NIHSS 평분、운동공능평분화감각공능평분적변화，관찰치료전후량조환자혈청 MMP-9、NOS、NO 수평적변화。결과관찰조총유효솔（82．14％）고우대조조（64.29％），차이유통계학의의（χ2＝4．553，P ＜0．05）。치료후，관찰조 NIHSS 평분균저우대조조，차이균유통계학의의（t ＝5．082、5．522、6．253，균 P ＜0．01）。치료3주，관찰조운동공능평분（69．54±17．82）분、감각공능평분（30．58±7．94）분，균고우대조조운동공능평분（52．93±14．66）분、감각공능평분（23．08±6．31）분，차이균유통계학의의（t ＝5．387、5．534，균 P ＜0．01）。치료후，관찰조혈청 MMP-9、NOS、NO 수평균저우대조조，차이균유통계학의의（균 P ＜0．01）。결론성뇌정주사액보조치료급성뇌경사료효현저，능구촉진환자신경공능적회복，개선운동공능화감각공능，병통과조절 MMP-9、NOS、NO 수평기도보호신경혈관적작용。
Objective To study the clinical effect of Xingnaojing injection in treating patients with acute cer-ebral infarction and its influence on serum matrix metalloproteinase 9 (MMP -9),nitric oxide (NO)and nitric oxide synthase (NOS).Methods 112 patients with acute cerebral infarction were randomly divided into two groups by ran-dom number table method,56 cases in each group.The control group received routine treatment for acute cerebral infarction.The observation group received routine treatment plus intravenous injection Xingnaojing.The changes of NIHSS score,motor function score and sensory function score in the two groups were compared before and after treat-ment.The serum levels of MMP -9,NOS and NO in the two groups were observed before and after treatment.Results The total effective rate of observation group was 82.14%,which was significantly higher than 64.29% in the control group (χ2 =4.553,P <0.05).After treatment,NIHSS scores of the observation group were significantly lower than the control group (t =5.082,5.522,6.253,all P <0.01 ).After treatment for 3 weeks,the motor function score (69.54 ±17.82)points,sensory function score (30.58 ±7.94)points of the observation group were significantly higher than (52.93 ±14.66)points and (23.08 ±6.31)points in the control group (t =5.387,5.534,all P <0.01).After treatment,the serum MMP -9,NOS,NO levels of the observation group were significantly lower than the control group (all P <0.01 ).Conclusion Xingnaojing injection in the treatment of acute cerebral infarction has good curative effect,it can promote the recovery of neurological function,improve motor function and sensory function, and by adjusting the MMP -9,NOS,NO levels to protect the nerve and blood vessel function.
