中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
20期
3139-3141,3142
,共4页
胃食管反流%兰索拉唑%莫沙必利%治疗结果
胃食管反流%蘭索拉唑%莫沙必利%治療結果
위식관반류%란색랍서%막사필리%치료결과
Gastroesophageal reflux%Lansoprazole%Mosapride%Treatment outcome
目的：分析研究兰索拉唑联合莫沙必利对胃食管反流患者的胃食管动力学及胃电活动指标的影响，以对其临床疗效进行研究。方法选取108例胃食管反流患者为研究对象，将108例患者按照随机数字表法随机分为对照组（兰索拉唑）和观察组（兰索拉唑联合莫沙必利）各54例，将两组患者治疗前与治疗后3周、6周、12周的胃食管动力学指标及胃电参数进行比较。结果观察组治疗后3周、6周、12周的胃食管动力学指标及胃电参数均明显好于对照组，且观察组治疗后胃食管动力学指标及胃电参数呈进行性升高（治疗后6周，t收缩＝3．12，t运动＝2．97，t频率＝2．36；t压力＝3．53，t松弛率＝6．24，t收缩比＝12．17；t频率．餐前＝2．57，t频率．餐后＝3．48，t幅值．餐前＝9．01，t幅值．餐后＝17．74；治疗后12周，t收缩＝4．97，t运动＝4．53，t频率＝2．99；t压力＝2．95，t松弛率＝7．92，t收缩比＝11．34；t频率．餐前＝2．90，t频率．餐后＝4．47，t幅值．餐前＝8．55，t幅值．餐后＝11．23，均 P ＜0．05）。结论兰索拉唑联合莫沙必利对胃食管反流患者的胃食管动力学及胃电活动指标的影响较大，因此对本病的治疗效果较好。
目的：分析研究蘭索拉唑聯閤莫沙必利對胃食管反流患者的胃食管動力學及胃電活動指標的影響，以對其臨床療效進行研究。方法選取108例胃食管反流患者為研究對象，將108例患者按照隨機數字錶法隨機分為對照組（蘭索拉唑）和觀察組（蘭索拉唑聯閤莫沙必利）各54例，將兩組患者治療前與治療後3週、6週、12週的胃食管動力學指標及胃電參數進行比較。結果觀察組治療後3週、6週、12週的胃食管動力學指標及胃電參數均明顯好于對照組，且觀察組治療後胃食管動力學指標及胃電參數呈進行性升高（治療後6週，t收縮＝3．12，t運動＝2．97，t頻率＝2．36；t壓力＝3．53，t鬆弛率＝6．24，t收縮比＝12．17；t頻率．餐前＝2．57，t頻率．餐後＝3．48，t幅值．餐前＝9．01，t幅值．餐後＝17．74；治療後12週，t收縮＝4．97，t運動＝4．53，t頻率＝2．99；t壓力＝2．95，t鬆弛率＝7．92，t收縮比＝11．34；t頻率．餐前＝2．90，t頻率．餐後＝4．47，t幅值．餐前＝8．55，t幅值．餐後＝11．23，均 P ＜0．05）。結論蘭索拉唑聯閤莫沙必利對胃食管反流患者的胃食管動力學及胃電活動指標的影響較大，因此對本病的治療效果較好。
목적：분석연구란색랍서연합막사필리대위식관반류환자적위식관동역학급위전활동지표적영향，이대기림상료효진행연구。방법선취108례위식관반류환자위연구대상，장108례환자안조수궤수자표법수궤분위대조조（란색랍서）화관찰조（란색랍서연합막사필리）각54례，장량조환자치료전여치료후3주、6주、12주적위식관동역학지표급위전삼수진행비교。결과관찰조치료후3주、6주、12주적위식관동역학지표급위전삼수균명현호우대조조，차관찰조치료후위식관동역학지표급위전삼수정진행성승고（치료후6주，t수축＝3．12，t운동＝2．97，t빈솔＝2．36；t압력＝3．53，t송이솔＝6．24，t수축비＝12．17；t빈솔．찬전＝2．57，t빈솔．찬후＝3．48，t폭치．찬전＝9．01，t폭치．찬후＝17．74；치료후12주，t수축＝4．97，t운동＝4．53，t빈솔＝2．99；t압력＝2．95，t송이솔＝7．92，t수축비＝11．34；t빈솔．찬전＝2．90，t빈솔．찬후＝4．47，t폭치．찬전＝8．55，t폭치．찬후＝11．23，균 P ＜0．05）。결론란색랍서연합막사필리대위식관반류환자적위식관동역학급위전활동지표적영향교대，인차대본병적치료효과교호。
Objective To study the influence of lansoprazole combined with mosapride for the gastric and e-sophageal dynamics and gastric electrical activity indexes of patients with gastroesophageal reflux,then to evaluate its clinical effects.Methods 108 patients with gastroesophageal reflux were randomly divided into the control group (lansoprazole)and observation group(lansoprazole combined with mosapride),54 cases in each group.The gastric and esophageal dynamics and gastric electrical activity indexes of the two groups before the treatment and at 3nd,6th and 12 th week after the treatment were compared.Results The gastric and esophageal dynamics and gastric electri-cal activity indexes of observation group at 3nd,6th and 12th week after the treatment were all obviously better than those of control group,those indexes of observation group increased progressively after treatment (6 weeks after treatment, tcontract =3.12,tmotion =2.97,tfrequency =2.36;tpressure =3.53,trelaxation rate =6.24,tshrinkage ratio =12.17;tfrequency preprandial =2.57,tfrequency postprandial =3.48,tamplitude preprandial =9.01,tamplitude postprandial =17.74;12 weeks after treatment,t contract =4.97,tmotion =4.53,tfrequency =2.99;tpressure =2.95,trelaxation rate =7.92,tshrinkage ratio =11.34;tfrequency preprandial =2.90, tfrequency postprandial =4.47,tamplitude preprandial =8.55,tamplitude postprandial =11.23,P <0.05 ).Conclusion The influence of lansoprazole combined with mosapride to the gastric and esophageal dynamics and gastric electrical activity indexes of patients with gastroesophageal reflux is great,so its treatment effect for the disease is better.
