中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
20期
3155-3157
,共3页
陈羡人%高雅文%包三裕%窦玲
陳羨人%高雅文%包三裕%竇玲
진이인%고아문%포삼유%두령
甲状腺功能亢进症%生长激素释放激素%因素分析,统计学
甲狀腺功能亢進癥%生長激素釋放激素%因素分析,統計學
갑상선공능항진증%생장격소석방격소%인소분석,통계학
Hyperthyroidism%Growth hormone -releasing hormone%Factor analysis,statistical
目的：探讨甲状腺功能亢进症患者血浆生长激素释放肽（Ghrelin）水平的变化及其影响因素。方法选择55例甲状腺功能亢进症患者作为观察组，同期55例健康体检者作为对照组，采用酶联免疫法对及甲状腺功能亢进症患者治疗前后的血浆进行测定，比较两组患者及甲状腺功能亢进症患者治疗前后体脂百分比、Ghrelin、S-TSH 及 FT3、FT4的水平，并分析 FT3、FT4、体脂百分比及 S-TSH 与血浆 Ghrelin 的关系。结果与对照组相比，观察组患者体脂百分比及 Ghrelin 与 S-TSH 的水平均较低，而 FT3、FT4水平较高，两组比较差异有统计学意义（t1＝5．021，t2＝9．628，t3＝23．054，t4＝29．325，t5＝28．967，均 P ＜0．05）；与治疗前相比，观察组患者治疗后体脂百分比及 Ghrelin 与 S-TSH 的水平均较高，而 FT3、FT4水平较低，治疗前后比较差异有统计学意义（t6＝5．282，t7＝8．651，t8＝21．835，t9＝27．126，t10＝26．855，均 P ＜0．05）；经相关性分析得出：FT3及 FT4与血浆 Ghrelin 水平呈负相关（r ＝－0．44，－0．39，均 P ＜0．05）；体脂百分比及 S-TSH 与血浆Ghrelin 水平呈正相关（r ＝0．31，0．33，均 P ＜0．05）。结论甲状腺功能亢进症患者血浆 Ghrelin 水平较健康人低，且其水平高低与 FT3、FT4、体脂百分比及 S-TSH 相关，以上指标的检测均对甲状腺功能亢进症患者病情的评估具有重要价值。
目的：探討甲狀腺功能亢進癥患者血漿生長激素釋放肽（Ghrelin）水平的變化及其影響因素。方法選擇55例甲狀腺功能亢進癥患者作為觀察組，同期55例健康體檢者作為對照組，採用酶聯免疫法對及甲狀腺功能亢進癥患者治療前後的血漿進行測定，比較兩組患者及甲狀腺功能亢進癥患者治療前後體脂百分比、Ghrelin、S-TSH 及 FT3、FT4的水平，併分析 FT3、FT4、體脂百分比及 S-TSH 與血漿 Ghrelin 的關繫。結果與對照組相比，觀察組患者體脂百分比及 Ghrelin 與 S-TSH 的水平均較低，而 FT3、FT4水平較高，兩組比較差異有統計學意義（t1＝5．021，t2＝9．628，t3＝23．054，t4＝29．325，t5＝28．967，均 P ＜0．05）；與治療前相比，觀察組患者治療後體脂百分比及 Ghrelin 與 S-TSH 的水平均較高，而 FT3、FT4水平較低，治療前後比較差異有統計學意義（t6＝5．282，t7＝8．651，t8＝21．835，t9＝27．126，t10＝26．855，均 P ＜0．05）；經相關性分析得齣：FT3及 FT4與血漿 Ghrelin 水平呈負相關（r ＝－0．44，－0．39，均 P ＜0．05）；體脂百分比及 S-TSH 與血漿Ghrelin 水平呈正相關（r ＝0．31，0．33，均 P ＜0．05）。結論甲狀腺功能亢進癥患者血漿 Ghrelin 水平較健康人低，且其水平高低與 FT3、FT4、體脂百分比及 S-TSH 相關，以上指標的檢測均對甲狀腺功能亢進癥患者病情的評估具有重要價值。
목적：탐토갑상선공능항진증환자혈장생장격소석방태（Ghrelin）수평적변화급기영향인소。방법선택55례갑상선공능항진증환자작위관찰조，동기55례건강체검자작위대조조，채용매련면역법대급갑상선공능항진증환자치료전후적혈장진행측정，비교량조환자급갑상선공능항진증환자치료전후체지백분비、Ghrelin、S-TSH 급 FT3、FT4적수평，병분석 FT3、FT4、체지백분비급 S-TSH 여혈장 Ghrelin 적관계。결과여대조조상비，관찰조환자체지백분비급 Ghrelin 여 S-TSH 적수평균교저，이 FT3、FT4수평교고，량조비교차이유통계학의의（t1＝5．021，t2＝9．628，t3＝23．054，t4＝29．325，t5＝28．967，균 P ＜0．05）；여치료전상비，관찰조환자치료후체지백분비급 Ghrelin 여 S-TSH 적수평균교고，이 FT3、FT4수평교저，치료전후비교차이유통계학의의（t6＝5．282，t7＝8．651，t8＝21．835，t9＝27．126，t10＝26．855，균 P ＜0．05）；경상관성분석득출：FT3급 FT4여혈장 Ghrelin 수평정부상관（r ＝－0．44，－0．39，균 P ＜0．05）；체지백분비급 S-TSH 여혈장Ghrelin 수평정정상관（r ＝0．31，0．33，균 P ＜0．05）。결론갑상선공능항진증환자혈장 Ghrelin 수평교건강인저，차기수평고저여 FT3、FT4、체지백분비급 S-TSH 상관，이상지표적검측균대갑상선공능항진증환자병정적평고구유중요개치。
Objective To study the changes of plasma growth hormone releasing peptide(Ghrelin)level and its influencing factors in patients with hyperthyroidism.Methods 55 patients with hyperthyroidism (observation group)and 55 healthy persons (control group)were selected.ELISA was used to detect plasma indicators before and after treatment.The level of body fat percentage,Ghrelin,S -TSH and FT3 ,FT4 of the two groups before and after treatment were compared,and the relationship between Ghrelin and FT3 ,FT4 ,percentage of body fat,plasma S -TSH was analyzed.Results Compared with the control group,the percentage of body fat,Ghrelin and S -TSH level in the observation group were lower,and FT3 ,FT4 levels were higher,there were significant differences between the two groups(t1 =5.021,t2 =9.628,t3 =23.054,t4 =29.325,t5 =28.967,P <0.05).Compared with before treatment,the body fat percentage,Ghrelin and S -TSH level of the observation group were higher after treatment,and FT3 ,FT4 levels were lower after treatment,the differences were statistically significant(t6 =5.282,t7 =8.651,t8 =21.835,t9 =27.126,t10 =26.855,P <0.05).The correlation analysis showed that FT3 and FT4 were negatively correlated with plasma Ghrelin level(r =-0.44,-0.39,P <0.05),the percentage body fat and S -TSH had positive relationship with plasma Ghrelin level (r =0.31,0.33,P <0.05).Conclusion The plasma Ghrelin level in the patients with hyperthyroidism is lower than healthy subjects,and its level is related with FT3 ,FT4 ,percentage of body fat and S -TSH,the detection of the above indicators has important value for the assessment of hyperthyroidism.
