实用骨科杂志
實用骨科雜誌
실용골과잡지
Journal of Practical Orthopaedics
2015年
10期
902-906
,共5页
骨水泥%磷酸钙%硅酸三钙%动物实验
骨水泥%燐痠鈣%硅痠三鈣%動物實驗
골수니%린산개%규산삼개%동물실험
calciumphosphate%bone cement%tricalcium silicate%animal experiments
目的:通过动物实验观察一种新型的硅酸盐可吸收性骨水泥的生物相容性、生物降解性和成骨特性。方法选取24只新西兰大白兔,在双侧股骨髁部钻取直径5 mm、高10 mm 圆柱形骨缺损,分别置入磷酸钙骨水泥(cal-cium phosphate cements,CPC,对照组)和磷酸钙-硅酸三钙复合骨水泥( calcium phosphate cements-calcium silicate, CPC-CS,材料组),术后4、8、12周分别处死8只动物,行 X 线检查和 HE 染色观察材料在体内的降解和新骨形成情况。结果4周时材料组和对照组材料无降解,HE 染色观察材料-骨组织之间均形成纤维层,8周时材料组材料降解变软,对照组材料降解不明显,对照组和材料组材料-骨之间纤维组织逐渐被新骨取代,材料组材料-骨之间结合面积明显较大,有较多新生骨;12周时,材料组材料降解明显,内部明显发生碎裂,有新生骨长入,对照组材料仅部分降解,对照组材料降解率为32.4%,材料组为45.4%,材料组降解速率显著高于对照组,差异有统计学意义(P <0.01)。结论磷酸钙-硅酸三钙复合骨水泥具备单纯磷酸钙类似的生物相容性,并且在力学强度、表面成骨活性和降解性方面有一定改善,通过进一步的优化有可能成为一种具有很好应用前景的新型生物活性骨修复材料。
目的:通過動物實驗觀察一種新型的硅痠鹽可吸收性骨水泥的生物相容性、生物降解性和成骨特性。方法選取24隻新西蘭大白兔,在雙側股骨髁部鑽取直徑5 mm、高10 mm 圓柱形骨缺損,分彆置入燐痠鈣骨水泥(cal-cium phosphate cements,CPC,對照組)和燐痠鈣-硅痠三鈣複閤骨水泥( calcium phosphate cements-calcium silicate, CPC-CS,材料組),術後4、8、12週分彆處死8隻動物,行 X 線檢查和 HE 染色觀察材料在體內的降解和新骨形成情況。結果4週時材料組和對照組材料無降解,HE 染色觀察材料-骨組織之間均形成纖維層,8週時材料組材料降解變軟,對照組材料降解不明顯,對照組和材料組材料-骨之間纖維組織逐漸被新骨取代,材料組材料-骨之間結閤麵積明顯較大,有較多新生骨;12週時,材料組材料降解明顯,內部明顯髮生碎裂,有新生骨長入,對照組材料僅部分降解,對照組材料降解率為32.4%,材料組為45.4%,材料組降解速率顯著高于對照組,差異有統計學意義(P <0.01)。結論燐痠鈣-硅痠三鈣複閤骨水泥具備單純燐痠鈣類似的生物相容性,併且在力學彊度、錶麵成骨活性和降解性方麵有一定改善,通過進一步的優化有可能成為一種具有很好應用前景的新型生物活性骨脩複材料。
목적:통과동물실험관찰일충신형적규산염가흡수성골수니적생물상용성、생물강해성화성골특성。방법선취24지신서란대백토,재쌍측고골과부찬취직경5 mm、고10 mm 원주형골결손,분별치입린산개골수니(cal-cium phosphate cements,CPC,대조조)화린산개-규산삼개복합골수니( calcium phosphate cements-calcium silicate, CPC-CS,재료조),술후4、8、12주분별처사8지동물,행 X 선검사화 HE 염색관찰재료재체내적강해화신골형성정황。결과4주시재료조화대조조재료무강해,HE 염색관찰재료-골조직지간균형성섬유층,8주시재료조재료강해변연,대조조재료강해불명현,대조조화재료조재료-골지간섬유조직축점피신골취대,재료조재료-골지간결합면적명현교대,유교다신생골;12주시,재료조재료강해명현,내부명현발생쇄렬,유신생골장입,대조조재료부부분강해,대조조재료강해솔위32.4%,재료조위45.4%,재료조강해속솔현저고우대조조,차이유통계학의의(P <0.01)。결론린산개-규산삼개복합골수니구비단순린산개유사적생물상용성,병차재역학강도、표면성골활성화강해성방면유일정개선,통과진일보적우화유가능성위일충구유흔호응용전경적신형생물활성골수복재료。
Objectiv To observe biocompatibility,biodegradability and osteogenesis characteristic of a new kind of silicate bone cement. Methods Bone defects of 5 mm × 10 mm were made at both femoral condyles of 24 rabbits,and calcium phos-phate cement(CPC)or calcium-phosphate-silicate composite bone cement(CPC-CS)were injected in bone defects of rabbits. We observe the degradation of material in the body and new bone formation through X-ray and HE staining in 4. 8. 12 weeks af-ter operation. Results Without degradation of materials at 4 weeks,the fiber tissues were formed between materials and bones. The CPC-CS materials degradation was more obvious than the CPC materials,the fiber tissues between materials and bones gradually were replaced by new bone tissues,more new bone was found in CPC-CS group at 8 weeks. At 12 weeks,the CPC-CS materials degradation was more obvious than the CPC materials,the CPC group degradation rate was 32. 4% ,CPC-CS group was 45. 4% ,the CPC-CS materials degradation rate was significantly higher than the CPC materials(P < 0. 01). Conclu-sion Calcium-phosphate-silicate composite bone cement has good biocompatibility,mechanical strength,osteogenesis charac-teristic and degradability. Calcium-phosphate-silicate composite bone cement will be a new bioactive bone repair material.