CAJ | 학술논문

目的：分析儿童嗜酸细胞胃肠炎（EGE）的临床表现及治疗。方法回顾性分析2012年6月至2014年6月收治的10例EGE患儿的临床资料及治疗随访情况。结果10例患儿中男6例，女4例，年龄9个月～14岁。学龄前及学龄儿童8例，临床表现腹痛（8例）、呕吐（4例）、腹泻（3例）、腹腔积液（3例）、皮疹（3例）、发热（2例）和低蛋白血症（2例）；婴幼儿2例，以腹泻、便血为主要表现。10例患儿外周血嗜酸细胞均升高，9例血IgE升高，1例C反应蛋白明显升高。内镜检查显示黏膜充血、肿胀、红斑、糜烂。多点活检病理示，嗜酸细胞计数>20个/HP。1例行腹腔镜探查后诊断明确。治疗包括规避饮食、奥美拉唑抑酸、抗过敏药等，其中4例患儿加用糖皮质激素治疗。随访半年～2年，10例中有1例病情反复。结论 EGE临床表现多样，内镜多点活检是诊断关键，腹腔镜探查有助于诊断；饮食治疗、糖皮质激素治疗效果较好。
목적：분석인동기산세포위장염（EGE）적림상표현급치료。방법회고성분석2012년6월지2014년6월수치적10례EGE환인적림상자료급치료수방정황。결과10례환인중남6례，녀4례，년령9개월～14세。학령전급학령인동8례，림상표현복통（8례）、구토（4례）、복사（3례）、복강적액（3례）、피진（3례）、발열（2례）화저단백혈증（2례）；영유인2례，이복사、편혈위주요표현。10례환인외주혈기산세포균승고，9례혈IgE승고，1례C반응단백명현승고。내경검사현시점막충혈、종창、홍반、미란。다점활검병리시，기산세포계수>20개/HP。1례행복강경탐사후진단명학。치료포괄규피음식、오미랍서억산、항과민약등，기중4례환인가용당피질격소치료。수방반년～2년，10례중유1례병정반복。결론 EGE림상표현다양，내경다점활검시진단관건，복강경탐사유조우진단；음식치료、당피질격소치료효과교호。
ObjectiveTo analyze clinical manifestations and treatment of eosinophilic gastroenteritis (EGE) in children.MethodsThe clinical data of 10 children with EGE under the treatment from June 2014 to June 2012 were analyzed retrospectively.ResultsThere were 10 children (6 males and 4 females) aged from 9 months to 14 years. Clin-ical symptoms of eight preschool and school age children included abdominal pain (8 cases), vomiting (4 cases), diarrhea (3 cases), ascites (3 cases), rash (3 cases), fever (2 cases) and hypoalbuminemia (2 cases). Clinical symptoms of two in-fant and toddler were diarrhea and hematochezia. Peripheral blood eosinophils were increased in 10 children. IgE was elevated in 9 children. One child had very high C-reactive protein. Endoscopic examination showed mucosal congestion, swelling, erythema, erosion. Multiple sites of biopsy showed eosinophil count> 20/HP. One child was diagnosed by lap-aroscopic exploration. The treatment included diet avoidance, omeprazole, anti-allergic drug. Four children were treated with corticosteroids. All children had been followed up for 6 months to 2 years. One child had relapsed.Conclusion The clinical manifestations of EGE are various. Endoscopic biopsy is necessary for diagnosis. Laparoscopy also is help-ful for diagnosis. Dietary and glucocorticoid therapy were effective.