山东医学高等专科学校学报
山東醫學高等專科學校學報
산동의학고등전과학교학보
Journal of Shandong Medical College
2015年
5期
327-330
,共4页
孙志清%付庆喜%涂丽香%孟凡华%车峰远
孫誌清%付慶喜%塗麗香%孟凡華%車峰遠
손지청%부경희%도려향%맹범화%차봉원
阿尔茨海默病%NADPH氧化酶%基因多态性%p22phox
阿爾茨海默病%NADPH氧化酶%基因多態性%p22phox
아이자해묵병%NADPH양화매%기인다태성%p22phox
Alzheimer’s disease%NADPH oxidase%Gene polymorphism%P22phox
目的:探讨p22phox C242T 基因多态性与汉族人群迟发性阿尔茨海默病(LOAD)的相关性。方法采用病例对照研究方法,选取276例L O A D患者和320例健康老年人作为研究对象,基因型通过 PCR‐RFLP 方法完成,比较不同基因型与 LOAD 的关系。结果未发现 p22phox C242T 多态性与LOAD存在相关,但经过 ApoE ε4进行分层分析,结果显示ApoE ε4携带者组CT+ T T基因型与等位基因 T 在LOAD和对照组中的分布存在显著差异( P <0.05),T 等位基因的存在使发生L O A D的风险增加了3.301倍(O R=3.301,95% C I=1.225–8.897, P =0.023)。结论 p22phox C242T 基因多态性可能与汉族人群ApoEε4携带者的LOAD发病存在相关性。
目的:探討p22phox C242T 基因多態性與漢族人群遲髮性阿爾茨海默病(LOAD)的相關性。方法採用病例對照研究方法,選取276例L O A D患者和320例健康老年人作為研究對象,基因型通過 PCR‐RFLP 方法完成,比較不同基因型與 LOAD 的關繫。結果未髮現 p22phox C242T 多態性與LOAD存在相關,但經過 ApoE ε4進行分層分析,結果顯示ApoE ε4攜帶者組CT+ T T基因型與等位基因 T 在LOAD和對照組中的分佈存在顯著差異( P <0.05),T 等位基因的存在使髮生L O A D的風險增加瞭3.301倍(O R=3.301,95% C I=1.225–8.897, P =0.023)。結論 p22phox C242T 基因多態性可能與漢族人群ApoEε4攜帶者的LOAD髮病存在相關性。
목적:탐토p22phox C242T 기인다태성여한족인군지발성아이자해묵병(LOAD)적상관성。방법채용병례대조연구방법,선취276례L O A D환자화320례건강노년인작위연구대상,기인형통과 PCR‐RFLP 방법완성,비교불동기인형여 LOAD 적관계。결과미발현 p22phox C242T 다태성여LOAD존재상관,단경과 ApoE ε4진행분층분석,결과현시ApoE ε4휴대자조CT+ T T기인형여등위기인 T 재LOAD화대조조중적분포존재현저차이( P <0.05),T 등위기인적존재사발생L O A D적풍험증가료3.301배(O R=3.301,95% C I=1.225–8.897, P =0.023)。결론 p22phox C242T 기인다태성가능여한족인군ApoEε4휴대자적LOAD발병존재상관성。
Objective To investigate potential associations of the p22phox C242T polymorphism with the risk of late‐onset AD (LOAD) in a northern Han Chinese population .Methods Patients with LOAD (N=276) and 320 control subjects were recruited for the study .Polymerase chain reaction‐restriction fragment length polymorphism was used to detect the genotypes .Results No significant differences were found be‐tween LOAD and p22phox C242T polymorphism ,but a significant association was obtained in the geno‐type and allele distributions of p22phox C242T between LOAD patients and controls in ApoE ε4 carriers ( P <0 .05) .The presence of allele T increased the risk of developing LOAD by 3 .301 fold (OR=3 .301 , 95% CI :1 .225‐8 .897 ,P = 0 .023) in APOE ε4 allele carriers .Conclusion These results suggested that p22phox C242T polymorphism has a possible role in changing the genetic susceptibility to LOAD in ApoEε4 carriers of this northern Han Chinese population .