中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
Evaluation and Analysis of Drug-Use in Hospitals of China
2015年
10期
1313-1315,1316
,共4页
游燕%潘智%谭方%黄丁英%易春霞%刘圆圆
遊燕%潘智%譚方%黃丁英%易春霞%劉圓圓
유연%반지%담방%황정영%역춘하%류원원
舒乳凝胶%急性毒性%皮肤刺激性%长期毒性
舒乳凝膠%急性毒性%皮膚刺激性%長期毒性
서유응효%급성독성%피부자격성%장기독성
Shuru gel%Acute toxicity%Skin irritation%Long-term toxicity
目的：分析舒乳凝胶的毒理学，为制定相关的卫生标准和防治措施提供理论依据。方法：把健康家兔分成5组，包括1组空白对照组（空白凝胶）和4组试验组（完整皮肤和破损皮肤组，分别使用高、低剂量舒乳凝胶），对舒乳凝胶的急性毒性、皮肤刺激性和长期毒性进行分析。结果：所有家兔均未出现死亡及明显的中毒症状，饮食情况正常，体质量正常增加，活动自如，给药期间各试验组动物体质量与对照组的差异无统计学意义（ P＞0.05）；舒乳凝胶低、高剂量组家兔单次给药后，完整皮肤和破损皮肤均未形成局部红斑和水肿，均未见刺激性，与对照组的差异无统计学意义（ P＞0.05）；对各组进行长期毒性反应试验可见，试验组家兔的体质量、血液学指标、血液生化指标和脏器系数、脏器组织形态学变化情况与对照组的差异均无统计学意义（ P＞0.05）。结论：不同剂量的舒乳凝胶对家兔无急性毒性、皮肤刺激性和长期毒性，为比较安全的外用药物。
目的：分析舒乳凝膠的毒理學，為製定相關的衛生標準和防治措施提供理論依據。方法：把健康傢兔分成5組，包括1組空白對照組（空白凝膠）和4組試驗組（完整皮膚和破損皮膚組，分彆使用高、低劑量舒乳凝膠），對舒乳凝膠的急性毒性、皮膚刺激性和長期毒性進行分析。結果：所有傢兔均未齣現死亡及明顯的中毒癥狀，飲食情況正常，體質量正常增加，活動自如，給藥期間各試驗組動物體質量與對照組的差異無統計學意義（ P＞0.05）；舒乳凝膠低、高劑量組傢兔單次給藥後，完整皮膚和破損皮膚均未形成跼部紅斑和水腫，均未見刺激性，與對照組的差異無統計學意義（ P＞0.05）；對各組進行長期毒性反應試驗可見，試驗組傢兔的體質量、血液學指標、血液生化指標和髒器繫數、髒器組織形態學變化情況與對照組的差異均無統計學意義（ P＞0.05）。結論：不同劑量的舒乳凝膠對傢兔無急性毒性、皮膚刺激性和長期毒性，為比較安全的外用藥物。
목적：분석서유응효적독이학，위제정상관적위생표준화방치조시제공이론의거。방법：파건강가토분성5조，포괄1조공백대조조（공백응효）화4조시험조（완정피부화파손피부조，분별사용고、저제량서유응효），대서유응효적급성독성、피부자격성화장기독성진행분석。결과：소유가토균미출현사망급명현적중독증상，음식정황정상，체질량정상증가，활동자여，급약기간각시험조동물체질량여대조조적차이무통계학의의（ P＞0.05）；서유응효저、고제량조가토단차급약후，완정피부화파손피부균미형성국부홍반화수종，균미견자격성，여대조조적차이무통계학의의（ P＞0.05）；대각조진행장기독성반응시험가견，시험조가토적체질량、혈액학지표、혈액생화지표화장기계수、장기조직형태학변화정황여대조조적차이균무통계학의의（ P＞0.05）。결론：불동제량적서유응효대가토무급성독성、피부자격성화장기독성，위비교안전적외용약물。
OBJECTIVE:To analyze the toxicology of shuru gel, and to provide theoretical basis for the formulation of hygienic standard and control measures.METHODS:Health rabbits were divided into 5 groups, including one blank control group( blank gel) and 4 experimental groups( intact-skin and damaged-skin model group,respectively with high and low doses of shuru gel) .The acute toxicity, skin irritation and long-term toricity were analyzed.RESULTS:All of the rats had no death and obviously toxic symptoms, with normal diet and freely activity, the body mass had an normal increase, there was no statistically significant difference of body mass between the control group and observation group (P>0.05).After administration of shuru gel of high dose and low dose in the rabbits, there were no local erythema, edema and irritation in intact-skin and damaged-skin, and with no statistically significant difference compared with the control group ( P >0.05 ) .From the long-term toxicity test of these groups, there was no statistically significant difference of the body mass, blood routine examination, blood biochemical indexes and coefficient of organs between the control group and observation group ( P >0.05 ) .CONCLUSIONS: Shuru gel of different dose has no acute toxicity, skin irritation and long-term toxicity in rabbits, it is safe for external medication.
