CAJ | 학술논문

目的：探讨2型糖尿病患者中亚临床甲状腺机能减退症与骨密度关系。方法选择32例2型糖尿病合并亚临床甲状腺功能减退患者作为观察组，36例甲状腺功能正常的2型糖尿病患者作为对照组，比较两组间腰椎1、2、3、4椎体和左侧股骨颈等部位的骨密度(BMD)。结果两组间在年龄、性别、BMI、糖尿病病程、糖化血红蛋白、FT3、FT4均无明显差异，观察组中TC、TG、LDL-C、HOMA-IR、TSH高于对照组，而HDL-C低于对照组，观察组左侧股骨颈BMD低于对照组，差异有统计学意义，两组间腰椎1、2、3、4椎体BMD无明显差异。结论2型糖尿病合并亚临床甲减者存在股骨颈的骨密度降低，胰岛素抵抗明显，同时存在血脂代谢紊乱。
목적：탐토2형당뇨병환자중아림상갑상선궤능감퇴증여골밀도관계。방법선택32례2형당뇨병합병아림상갑상선공능감퇴환자작위관찰조，36례갑상선공능정상적2형당뇨병환자작위대조조，비교량조간요추1、2、3、4추체화좌측고골경등부위적골밀도(BMD)。결과량조간재년령、성별、BMI、당뇨병병정、당화혈홍단백、FT3、FT4균무명현차이，관찰조중TC、TG、LDL-C、HOMA-IR、TSH고우대조조，이HDL-C저우대조조，관찰조좌측고골경BMD저우대조조，차이유통계학의의，량조간요추1、2、3、4추체BMD무명현차이。결론2형당뇨병합병아림상갑감자존재고골경적골밀도강저，이도소저항명현，동시존재혈지대사문란。
Objective: To investigate relationship between subclinical hypothyroidism (SCH) and bone mineral density (BMD) in the patients with type 2 diabetes. Methods: Totally 68 patients with type 2 diabetes were divided into observation group (type 2 diabetic patients with SCH group, n=32) and control group (type 2 diabetic patients with euthyroid, n=36). The patient’s general information, past medical history, laboratory test results, lumbar vertebrae 1-4 and left femoral neck BMD using dual-energy X-ray absorptiometry were analyzed.Results: There were no significant difference in age, sex, BMI, duration of diabetes, Glycosylated hemoglobin (HbA1c), serum free triiodothyronine (FT3) level, serum free thyroxine (FT4) level between two groups. The total cholesterol, triglycerides, LDL cholesterol, homeostasis model assessment index for insulin resistance (HOMA-IR), thyroid stimulating hormone (TSH) in observation group was significantly higher than those in control group, but significantly lower for the HDL cholesterol and the femoral neck BMD, and there was no significant difference of lumbar vertebrae 1-4 BMD between two groups.Conclusion: Type 2 diabetic patients with SCH are associated with lower femoral neck BMD, heavier insulin resistance and dyslipidemia.