CAJ | 학술논문

目的：探讨嗜酸性粒细胞增多症（HES）合并脑梗死的危险因素。方法采用回顾性病例对照研究的方法，调查了2005年3月至2015年3月期间陕西省人民医院、西安交通大学附属第二医院连续收治住院的HES患者的病历数据和随访资料，分析患者的病程、实验室检查、影像学检查、治疗方法等临床资料，根据是否发生脑梗死进行相关危险因素分析。结果120例HES患者中有8例患者出现脑梗死，发病率为6.7%，其中男性6例，女性2例。实验室生化指标中肌酸激酶同工酶及肌钙蛋白T在脑梗死患者中较未发生脑梗死的患者明显升高，差异具有统计学意义（P＜0.05）。结论 HES患者脑梗死风险较高，其脑梗死发病机制可能与HES所致心内膜和心肌损伤、坏死，血栓形成，栓子脱落发生栓塞有关。
목적：탐토기산성립세포증다증（HES）합병뇌경사적위험인소。방법채용회고성병례대조연구적방법，조사료2005년3월지2015년3월기간합서성인민의원、서안교통대학부속제이의원련속수치주원적HES환자적병력수거화수방자료，분석환자적병정、실험실검사、영상학검사、치료방법등림상자료，근거시부발생뇌경사진행상관위험인소분석。결과120례HES환자중유8례환자출현뇌경사，발병솔위6.7%，기중남성6례，녀성2례。실험실생화지표중기산격매동공매급기개단백T재뇌경사환자중교미발생뇌경사적환자명현승고，차이구유통계학의의（P＜0.05）。결론 HES환자뇌경사풍험교고，기뇌경사발병궤제가능여HES소치심내막화심기손상、배사，혈전형성，전자탈락발생전새유관。
Objective To investigate the relative risk factors of cerebral infarction in the patients with hypereosinophilic syndrome (HES). Methods A retrospective case-control study was carried out on all the consecutive in-patients diagnosed with eosinophilia in the Shaanxi Provincial People’s Hospital and the Second Affiliated Hospital of Xi’an Jiaotong University from March 2005 to March 2015. Their clinical data and follow-up information were collected. Disease course, laboratory results, radiological results, and treatment recordings were analyzed for their correlation with the occurrence of cerebral infarction. Results A total of 120 HES patients were enrolled in this study, and 8 of them (6 males and 2 females) suffered from acute cerebral infarction, with an incidence of 6.7%. Laboratory examination indicated that the serum levels of creatine kinase isoenzyme and troponin T were obviously higher in those with acute cerebral infarction than those without (P<0.05). Conclusion HES patients are at high risk of cerebral infarction, which might be due to the impairment and necrosis of endocardium and myocardium, thrombogenesis, and embolism.