CAJ | 학술논문

糖尿病并发症可引起人体心、脑和肾等重要组织和器官损害，严重危害人类健康，但其发病机制并不十分清楚。近年研究发现微小RNA（microRNA，miRNA）在糖尿病及其并发症的发生发展中起重要作用。miRNA是真核生物中一类长度约22～25个核苷酸的内源性非编码小分子RNA，通过转录后机制调控其下游靶基因的表达，进而影响疾病的病理生理学过程。其中miRNA-200（miR-200）家族对糖尿病及其并发症的调控研究较多。miR-200家族不仅对胰岛素相关信号通路具有调控作用，在糖尿病微血管及大血管并发症中也发挥重要调控作用。因此，探讨miR-200家族与糖尿病及其并发症之间的关系，可为糖尿病及其并发症的诊断及治疗提供新的思路。
당뇨병병발증가인기인체심、뇌화신등중요조직화기관손해，엄중위해인류건강，단기발병궤제병불십분청초。근년연구발현미소RNA（microRNA，miRNA）재당뇨병급기병발증적발생발전중기중요작용。miRNA시진핵생물중일류장도약22～25개핵감산적내원성비편마소분자RNA，통과전록후궤제조공기하유파기인적표체，진이영향질병적병리생이학과정。기중miRNA-200（miR-200）가족대당뇨병급기병발증적조공연구교다。miR-200가족불부대이도소상관신호통로구유조공작용，재당뇨병미혈관급대혈관병발증중야발휘중요조공작용。인차，탐토miR-200가족여당뇨병급기병발증지간적관계，가위당뇨병급기병발증적진단급치료제공신적사로。
The complications of diabetes usually cause target organ damage, such as the heart, brain, kidneys and others, and are seriously hazardous to human health. But the underlying mechanism is still not very clear. Recent studies indicated that microRNA (miRNA) plays an important role in the occurrence and development of diabetes and its complications. miRNA, An endogenous small non-coding RNA molecule (containing about 22-25 nucleotides) in eukaryotes, regulates the expression of its downstream target genes at post-transcriptional level, and then influences the pathophysiology of diseases. Many studies have reported that miRNA-200 (miR-200) family plays certain regulative roles in diabetes and its complications. The family not only regulates insulin related signal pathway, but also plays an important role in diabetic microvascular and macrovascular complications. Therefore, to explore the relationship of miR-200 family with diabetes and its complications would provide a new train of thought for diagnosis and treatment of diabetes and its complications.