CAJ | 학술논문

目的：通过探讨氢质子磁共振波谱成像与足月新生儿缺氧缺血性脑病代谢变化的关系，以评估其在诊断新生儿缺氧缺血性脑病的应用价值。方法收集我院4年间经临床确诊为新生儿缺氧缺血性脑病的足月新生儿共37例为实验组，随机抽出同期在我院产科出生健康的新生儿共11人，为对照组。所有研究对象于出生11天内进行头颅氢质子磁共振波谱检查，测量右侧基底节各代谢产物波峰下面积值。在出生后6月时分别做发育商试，并对上述资料进行统计学分析。结果①新生儿缺血缺氧性脑病早期可引起颅内右侧基底节naa/cr、lac/cr、Glx/cr化合物的改变，且病变越重，相关的改变越明显。②新生儿缺血缺氧性脑病Mrs各代谢物的改变与预后高度相关。结论氢质子磁共振波谱对新生儿缺氧缺血性脑病的临床诊断具有重要临床意义，而且无创伤及辐射值得深入研究及推广。
목적：통과탐토경질자자공진파보성상여족월신생인결양결혈성뇌병대사변화적관계，이평고기재진단신생인결양결혈성뇌병적응용개치。방법수집아원4년간경림상학진위신생인결양결혈성뇌병적족월신생인공37례위실험조，수궤추출동기재아원산과출생건강적신생인공11인，위대조조。소유연구대상우출생11천내진행두로경질자자공진파보검사，측량우측기저절각대사산물파봉하면적치。재출생후6월시분별주발육상시，병대상술자료진행통계학분석。결과①신생인결혈결양성뇌병조기가인기로내우측기저절naa/cr、lac/cr、Glx/cr화합물적개변，차병변월중，상관적개변월명현。②신생인결혈결양성뇌병Mrs각대사물적개변여예후고도상관。결론경질자자공진파보대신생인결양결혈성뇌병적림상진단구유중요림상의의，이차무창상급복사치득심입연구급추엄。
Objective: to discuss relationship between proton magnetic resonance imaging and metabolism changes of mature neonates with hypoxic ischemic encephalopathy, and evaluate its application value of diagnosing neonatal hypoxic ischemic encephalopathy. Method: collect a total of 37 cases mature neonatal with definite clinical diagnosis of hypoxic ischemic encephalopathy in our hospital during the past 4 years as experiment group, and choose a total of 11 cases healthy neonatal at obstetrics department of our hospital randomly at the same period as control group. all cases were carried on head proton magnetic resonance spectroscopy within 11 days after birth, and test area under peak of right side basal ganglia metabolites. 6 months after birth, they were carried on development quotient, and analyze concern data statistically. Result:①neonatal hypoxic ischemic encephalopathy at early stage may cause compound changes of naa/cr, lac/cr and Glx/cr at right basal ganglia of brain, and changes are obvious with severe lesion.②changes of Mrs metabolites in neonatal hypoxic ischemic encephalopathy are highly correlated with prognosis. Conclusion:Proton magnetic resonance spectroscopy has important clinical signiifcance in diagnosing neonatal hypoxic ischemic encephalopathy, without injury and radiation, which is worthy of further study and promotion.