中国现代中药
中國現代中藥
중국현대중약
Modern Chinese Medicine
2015年
9期
957-961
,共5页
李跃辉%王银%袁清照%张水寒
李躍輝%王銀%袁清照%張水寒
리약휘%왕은%원청조%장수한
晕瘫通脑片%Box-Behnken 效应面法%总评“归一值”%葛根素%浸膏得率
暈癱通腦片%Box-Behnken 效應麵法%總評“歸一值”%葛根素%浸膏得率
훈탄통뇌편%Box-Behnken 효응면법%총평“귀일치”%갈근소%침고득솔
Yuntan Tongnao slices%Box-Behnken design-response surface methodology%overall desirability%puerarin%yield of extract
目的:优选晕瘫通脑片的提取工艺。方法:以葛根素提取量和浸膏得率的综合评分为评价指标,在单因素试验基础上,通过 Box-Behnken 效应面法考察浸泡时间、加水量、提取时间对提取工艺的影响。结果:优选得到晕瘫通脑片的最佳提取工艺为加水8.6倍量,浸泡63.8 min 后提取128.4 min,提取两次。结论:通过Box-Behnken 效应面法及总评“归一值”(OD)为评价系统优选的提取工艺稳定、简便易行、预测性好,可为晕瘫通脑片的工艺研究提供参考。
目的:優選暈癱通腦片的提取工藝。方法:以葛根素提取量和浸膏得率的綜閤評分為評價指標,在單因素試驗基礎上,通過 Box-Behnken 效應麵法攷察浸泡時間、加水量、提取時間對提取工藝的影響。結果:優選得到暈癱通腦片的最佳提取工藝為加水8.6倍量,浸泡63.8 min 後提取128.4 min,提取兩次。結論:通過Box-Behnken 效應麵法及總評“歸一值”(OD)為評價繫統優選的提取工藝穩定、簡便易行、預測性好,可為暈癱通腦片的工藝研究提供參攷。
목적:우선훈탄통뇌편적제취공예。방법:이갈근소제취량화침고득솔적종합평분위평개지표,재단인소시험기출상,통과 Box-Behnken 효응면법고찰침포시간、가수량、제취시간대제취공예적영향。결과:우선득도훈탄통뇌편적최가제취공예위가수8.6배량,침포63.8 min 후제취128.4 min,제취량차。결론:통과Box-Behnken 효응면법급총평“귀일치”(OD)위평개계통우선적제취공예은정、간편역행、예측성호,가위훈탄통뇌편적공예연구제공삼고。
Objective:To optimize extraction process of Yuntan Tongnao tablets by Box-Behnken design-response surface methodology.Methods:On the basis of single factor tests,Box-Behnken experimental design was employed to investigate effects of the extraction time,water amount and the soaking time on puerarin and yield of the extract.Results:The optimized processing parameters were as follows:soaking time 63.8 minutes,8.6 times volume of water,extract time 128.4minutes,twice extraction.Conclusion: The optimized extraction process is proved to be stable, simple, good predictability by Box-Behnken design-response surface methodology and overall desirability,it provides a basis for technology research of Yuntan Tongnao tablets.