中华精神科杂志
中華精神科雜誌
중화정신과잡지
Chinese Journal of Psychiatry
2015年
5期
292-296
,共5页
精神分裂症%青少年%认知功能
精神分裂癥%青少年%認知功能
정신분렬증%청소년%인지공능
Schizophrenia%Adolescent%Cognitive function
目的 探讨首次发病青少年精神分裂症患者认知功能的特点以及与精神症状的相关性.方法 采用中文版认知功能成套测验——共识版中的连线测验A、范畴流畅、符号编码、韦氏记忆量表-第三版空间广度测验、霍普金斯词汇学习测验-修订版、简易视觉空间记忆测验-修订版、持续操作测验-相对配对、迷宫测评25例青少年精神分裂症患者(患者组)治疗前后的信息处理速度、工作记忆、言语学习、视觉学习、注意/警觉性、推理和问题解决的功能;使用PANSS评估患者治疗前后精神症状,认知功能与PANSS各因子分进行相关性分析.同时对29名健康青少年对照者(对照组)进认知功能测评.结果 患者组治疗前连线测验A完成时间显著长于对照组[(57.1±31.5)分与(40.9±15.0)分,t=-2.44,P＜0.05];符号编码[(38.8±11.0)分与(56.2±10.3)分,t=5.88,P＜0.01]、范畴流畅性[(14.9±4.1)分与(18.5±4.8)分,t=2.88,P＜0.05]、韦氏记忆量表-第三版空间广度测验[(17.0±3.3)分与(19.6±2.3)分,t=3.12,P＜0.05]、霍普金斯词汇学习测验-修订版[(19.6±5.6)分与(26.7±4.9)分,t=4.89,P＜0.01]、简易视觉空间记忆测验-修订版[(21.3±6.2)分与(28.9±5.3)分,t=4.55,P＜0.01]、迷宫[(9.3±6.1)分与(14.4±6.1)分,t=2.29,P＜0.05]的得分均显著低于对照组,持续操作测验-相对配对总分与对照组相比差异无统计学意义;患者组治疗前后认知功能差异无统计学意义;患者组治疗前认知功能与PANSS各因子分之间无相关性.结论 首次发病青少年精神分裂症患者发病初期存在广泛的认知功能损害,认知功能独立于精神症状,不随精神症状的缓解而改善.
目的 探討首次髮病青少年精神分裂癥患者認知功能的特點以及與精神癥狀的相關性.方法 採用中文版認知功能成套測驗——共識版中的連線測驗A、範疇流暢、符號編碼、韋氏記憶量錶-第三版空間廣度測驗、霍普金斯詞彙學習測驗-脩訂版、簡易視覺空間記憶測驗-脩訂版、持續操作測驗-相對配對、迷宮測評25例青少年精神分裂癥患者(患者組)治療前後的信息處理速度、工作記憶、言語學習、視覺學習、註意/警覺性、推理和問題解決的功能;使用PANSS評估患者治療前後精神癥狀,認知功能與PANSS各因子分進行相關性分析.同時對29名健康青少年對照者(對照組)進認知功能測評.結果 患者組治療前連線測驗A完成時間顯著長于對照組[(57.1±31.5)分與(40.9±15.0)分,t=-2.44,P＜0.05];符號編碼[(38.8±11.0)分與(56.2±10.3)分,t=5.88,P＜0.01]、範疇流暢性[(14.9±4.1)分與(18.5±4.8)分,t=2.88,P＜0.05]、韋氏記憶量錶-第三版空間廣度測驗[(17.0±3.3)分與(19.6±2.3)分,t=3.12,P＜0.05]、霍普金斯詞彙學習測驗-脩訂版[(19.6±5.6)分與(26.7±4.9)分,t=4.89,P＜0.01]、簡易視覺空間記憶測驗-脩訂版[(21.3±6.2)分與(28.9±5.3)分,t=4.55,P＜0.01]、迷宮[(9.3±6.1)分與(14.4±6.1)分,t=2.29,P＜0.05]的得分均顯著低于對照組,持續操作測驗-相對配對總分與對照組相比差異無統計學意義;患者組治療前後認知功能差異無統計學意義;患者組治療前認知功能與PANSS各因子分之間無相關性.結論 首次髮病青少年精神分裂癥患者髮病初期存在廣汎的認知功能損害,認知功能獨立于精神癥狀,不隨精神癥狀的緩解而改善.
목적 탐토수차발병청소년정신분렬증환자인지공능적특점이급여정신증상적상관성.방법 채용중문판인지공능성투측험——공식판중적련선측험A、범주류창、부호편마、위씨기억량표-제삼판공간엄도측험、곽보금사사회학습측험-수정판、간역시각공간기억측험-수정판、지속조작측험-상대배대、미궁측평25례청소년정신분렬증환자(환자조)치료전후적신식처리속도、공작기억、언어학습、시각학습、주의/경각성、추리화문제해결적공능;사용PANSS평고환자치료전후정신증상,인지공능여PANSS각인자분진행상관성분석.동시대29명건강청소년대조자(대조조)진인지공능측평.결과 환자조치료전련선측험A완성시간현저장우대조조[(57.1±31.5)분여(40.9±15.0)분,t=-2.44,P＜0.05];부호편마[(38.8±11.0)분여(56.2±10.3)분,t=5.88,P＜0.01]、범주류창성[(14.9±4.1)분여(18.5±4.8)분,t=2.88,P＜0.05]、위씨기억량표-제삼판공간엄도측험[(17.0±3.3)분여(19.6±2.3)분,t=3.12,P＜0.05]、곽보금사사회학습측험-수정판[(19.6±5.6)분여(26.7±4.9)분,t=4.89,P＜0.01]、간역시각공간기억측험-수정판[(21.3±6.2)분여(28.9±5.3)분,t=4.55,P＜0.01]、미궁[(9.3±6.1)분여(14.4±6.1)분,t=2.29,P＜0.05]적득분균현저저우대조조,지속조작측험-상대배대총분여대조조상비차이무통계학의의;환자조치료전후인지공능차이무통계학의의;환자조치료전인지공능여PANSS각인자분지간무상관성.결론 수차발병청소년정신분렬증환자발병초기존재엄범적인지공능손해,인지공능독립우정신증상,불수정신증상적완해이개선.
Objective The aim of this study was to investigate the feature of cognitive function in first-episode adolescent-onset schizophrenia,and to explore the correlation between cognitive function and clinical symptoms.Method Twenty-five first-episode drug-naive patients with adolescent-onset schizophrenia at baseline and after a 12-week treatment were assessed with the speed of proceeding,working memory,verbal learning,visual learning,attention/vigilance,and reasoning and problem solving,using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery.The PANSS was used to evaluate clinical symptoms.The correlation between cognitive function and clinical symptoms in schizophrenia was assessed.The cognitive function was also examined in twenty-nine healthy controls at baseline.Results Compared with the controls,the patients showed significant differences in the speed of proceeding (57.1±31.5 vs.40.9± 15.0,t=-2.44,P＜0.05;38.8± 11.0 vs.56.2± 10.3,t=5.88,P＜0.01;14.9±4.1 vs.18.5±4.8,t=2.88,P＜0.05),working memory (17.0±3.3 vs.19.6±2.3,t=3.12,P＜0.05),verbal learning (19.6±5.6 vs.26.7±4.9,t=4.89,P＜0.01),visual learning (21.3±6.2 vs.28.9±5.3,t=4.55,P＜0.01),and reasoning and problem solving (9.3±6.1 vs.14.4±6.1,t=2.29,P＜0.05),except for attention/vigilance at baseline.There were no significant differences in all cognitive function test scores between baseline and 12 week treatment (all P＞0.05).No significant correlations were found between all cognitive function tests scores and PANSS score.Conclusion There are extensive,but not all,cognitive impairment in first-episode drug-naive patients with adolescent-onset schizophrenia.The cognitive impairment of patients may be independent to psychiatric symptoms.
