中国综合临床
中國綜閤臨床
중국종합림상
Clinical Medicine of China
2015年
10期
875-878
,共4页
甲氨蝶呤%儿童%急性淋巴细胞白血病%不良反应
甲氨蝶呤%兒童%急性淋巴細胞白血病%不良反應
갑안접령%인동%급성림파세포백혈병%불량반응
Methotrexate%Childhood%Acute lymphoblastic leukemia%Adverse reactions
目的 观察两种不同大剂量甲氨蝶呤(MTX)治疗小儿急性淋巴细胞白血病的不良反应.方法 小儿急性淋巴细胞白血病患儿25例,标危组13例予3.0 g/m2(体表面积)甲氨蝶呤,中高危组12例予5.0 g/m2 MTX,首剂MTX(总量的1/6)开始后36 h四氢叶酸钙(CF)解救,对比两组不良反应发生率.结果 消化道反应、肝功能损害、黏膜损害是大剂量甲氨蝶呤常见的不良反应,两组在各不良反应发生率方面差异均无统计学意义(P均＞0.05).结论 大剂量MTX对全身毒性的大小不是依据MTX的给药剂量而定,而主要与MTX的血药浓度及持续时间有关.
目的 觀察兩種不同大劑量甲氨蝶呤(MTX)治療小兒急性淋巴細胞白血病的不良反應.方法 小兒急性淋巴細胞白血病患兒25例,標危組13例予3.0 g/m2(體錶麵積)甲氨蝶呤,中高危組12例予5.0 g/m2 MTX,首劑MTX(總量的1/6)開始後36 h四氫葉痠鈣(CF)解救,對比兩組不良反應髮生率.結果 消化道反應、肝功能損害、黏膜損害是大劑量甲氨蝶呤常見的不良反應,兩組在各不良反應髮生率方麵差異均無統計學意義(P均＞0.05).結論 大劑量MTX對全身毒性的大小不是依據MTX的給藥劑量而定,而主要與MTX的血藥濃度及持續時間有關.
목적 관찰량충불동대제량갑안접령(MTX)치료소인급성림파세포백혈병적불량반응.방법 소인급성림파세포백혈병환인25례,표위조13례여3.0 g/m2(체표면적)갑안접령,중고위조12례여5.0 g/m2 MTX,수제MTX(총량적1/6)개시후36 h사경협산개(CF)해구,대비량조불량반응발생솔.결과 소화도반응、간공능손해、점막손해시대제량갑안접령상견적불량반응,량조재각불량반응발생솔방면차이균무통계학의의(P균＞0.05).결론 대제량MTX대전신독성적대소불시의거MTX적급약제량이정,이주요여MTX적혈약농도급지속시간유관.
Objective To observe the adverse effects of two different high-dose methotrexate(MTX) in pediatric acute lymphoblastic leukemia.Methods Totally 25 cases acute lymphoblastic leukemia children were grouped according to the risk factor,the low-risk group(13 patients) received MTX 3 g/m2 continuous infusion and high-risk group(12 patients) received MTX 5 g/m2 continuous infusion.Using Calcium Folinate(CF) 36 h after first dose MTX (1/6 total dose) ,then compare the incidence rates and the severity of the MTX of adverse effects.Results Gastrointestinal syptoms, hver damage, mucosal damage were the most common adverse effects after high-dose MTX infusion, the two groups had no significant difference (P ＞ 0.05).Conclusion The incidence rates and the severity of adverse reactions of high dose MTX were related directly with the level and the persistencetime of the plasma concentration.
