中华精神科杂志
中華精神科雜誌
중화정신과잡지
Chinese Journal of Psychiatry
2015年
5期
284-291
,共8页
杨海晨%李琳玲%彭红军%刘铁榜%秋云海%荣晗%冀二妮%毕建强%张建
楊海晨%李琳玲%彭紅軍%劉鐵榜%鞦雲海%榮晗%冀二妮%畢建彊%張建
양해신%리림령%팽홍군%류철방%추운해%영함%기이니%필건강%장건
重性抑郁障碍%轻躁狂症状%静息态%功能磁共振%低频振幅
重性抑鬱障礙%輕躁狂癥狀%靜息態%功能磁共振%低頻振幅
중성억욱장애%경조광증상%정식태%공능자공진%저빈진폭
Major depressive disorder%Hypomanic symptoms%Resting state%Functional magnetic resonance imaging%Amplitude of low-frequency fluctuation
目的 探讨伴轻躁狂症状的抑郁症患者在静息状态下脑功能磁共振低频振幅的特异性.方法 对54例处于抑郁发作的抑郁症患者及36名健康对照者进行静息态脑功能磁共振扫描.抑郁症患者经HCL-32自评,<12分为抑郁症不伴轻躁狂症状,≥12分为抑郁症伴轻躁狂症状.HCL-32评分<12分31例,≥12分23例,考虑性别、年龄等因素匹配,最后纳入分析的抑郁症不伴轻躁狂症状组及抑郁症伴轻躁狂症状组每组各19例,相匹配的健康对照者19名(对照组).利用静息态脑功能活动低频振幅指标,对被试者的静息态脑功能活动进行分析和比较.抑郁症患者的HCL-32评分与全脑的低频振幅值进行相关分析.结果 抑郁症患者与健康对照者相比,低频振幅值在较多脑区差异有统计学意义.与不伴轻躁狂症状的抑郁症患者比较,伴轻躁狂症状的抑郁症患者在双侧眶额皮质[左眶额回:MNI坐标(x、y、z):-34、56、-10,t=5.26;右眶额回:MNI坐标(x、y、z):20、66、-2,t=4.93]、额上回[左额上回:MNI坐标(x、y、z):-4、66、8,t=4.12;右额上回:MNI坐标(x、y、z):14、56、18,t=3.97]低频振幅值显著增高(P<0.05);而在双侧丘脑、左侧梭回则显著降低(P<0.05).抑郁症患者的HCL-32评分与全脑的低频振幅值的相关分析显示,HCL-32评分与双侧眶额皮质(左额中回、右额中回、右上额回)的低频振幅值呈正相关(r=0.363、0.426、0.405,均P<0.05),与左侧丘脑、左侧梭回低频振幅值呈负相关(r=-0.352,P<0.05;r=-0.468,P<0.01).结论 与不伴轻躁狂症状的抑郁症患者相比,伴轻躁狂症状的抑郁症患者静息态脑低频振幅具有特异性,尤其表现为双侧眶额回低频振幅值增高,左侧丘脑及左侧梭回低频振幅值降低.该结果或许可以作为HCL-32筛查阳性抑郁症患者的生物学标记.
目的 探討伴輕躁狂癥狀的抑鬱癥患者在靜息狀態下腦功能磁共振低頻振幅的特異性.方法 對54例處于抑鬱髮作的抑鬱癥患者及36名健康對照者進行靜息態腦功能磁共振掃描.抑鬱癥患者經HCL-32自評,<12分為抑鬱癥不伴輕躁狂癥狀,≥12分為抑鬱癥伴輕躁狂癥狀.HCL-32評分<12分31例,≥12分23例,攷慮性彆、年齡等因素匹配,最後納入分析的抑鬱癥不伴輕躁狂癥狀組及抑鬱癥伴輕躁狂癥狀組每組各19例,相匹配的健康對照者19名(對照組).利用靜息態腦功能活動低頻振幅指標,對被試者的靜息態腦功能活動進行分析和比較.抑鬱癥患者的HCL-32評分與全腦的低頻振幅值進行相關分析.結果 抑鬱癥患者與健康對照者相比,低頻振幅值在較多腦區差異有統計學意義.與不伴輕躁狂癥狀的抑鬱癥患者比較,伴輕躁狂癥狀的抑鬱癥患者在雙側眶額皮質[左眶額迴:MNI坐標(x、y、z):-34、56、-10,t=5.26;右眶額迴:MNI坐標(x、y、z):20、66、-2,t=4.93]、額上迴[左額上迴:MNI坐標(x、y、z):-4、66、8,t=4.12;右額上迴:MNI坐標(x、y、z):14、56、18,t=3.97]低頻振幅值顯著增高(P<0.05);而在雙側丘腦、左側梭迴則顯著降低(P<0.05).抑鬱癥患者的HCL-32評分與全腦的低頻振幅值的相關分析顯示,HCL-32評分與雙側眶額皮質(左額中迴、右額中迴、右上額迴)的低頻振幅值呈正相關(r=0.363、0.426、0.405,均P<0.05),與左側丘腦、左側梭迴低頻振幅值呈負相關(r=-0.352,P<0.05;r=-0.468,P<0.01).結論 與不伴輕躁狂癥狀的抑鬱癥患者相比,伴輕躁狂癥狀的抑鬱癥患者靜息態腦低頻振幅具有特異性,尤其錶現為雙側眶額迴低頻振幅值增高,左側丘腦及左側梭迴低頻振幅值降低.該結果或許可以作為HCL-32篩查暘性抑鬱癥患者的生物學標記.
목적 탐토반경조광증상적억욱증환자재정식상태하뇌공능자공진저빈진폭적특이성.방법 대54례처우억욱발작적억욱증환자급36명건강대조자진행정식태뇌공능자공진소묘.억욱증환자경HCL-32자평,<12분위억욱증불반경조광증상,≥12분위억욱증반경조광증상.HCL-32평분<12분31례,≥12분23례,고필성별、년령등인소필배,최후납입분석적억욱증불반경조광증상조급억욱증반경조광증상조매조각19례,상필배적건강대조자19명(대조조).이용정식태뇌공능활동저빈진폭지표,대피시자적정식태뇌공능활동진행분석화비교.억욱증환자적HCL-32평분여전뇌적저빈진폭치진행상관분석.결과 억욱증환자여건강대조자상비,저빈진폭치재교다뇌구차이유통계학의의.여불반경조광증상적억욱증환자비교,반경조광증상적억욱증환자재쌍측광액피질[좌광액회:MNI좌표(x、y、z):-34、56、-10,t=5.26;우광액회:MNI좌표(x、y、z):20、66、-2,t=4.93]、액상회[좌액상회:MNI좌표(x、y、z):-4、66、8,t=4.12;우액상회:MNI좌표(x、y、z):14、56、18,t=3.97]저빈진폭치현저증고(P<0.05);이재쌍측구뇌、좌측사회칙현저강저(P<0.05).억욱증환자적HCL-32평분여전뇌적저빈진폭치적상관분석현시,HCL-32평분여쌍측광액피질(좌액중회、우액중회、우상액회)적저빈진폭치정정상관(r=0.363、0.426、0.405,균P<0.05),여좌측구뇌、좌측사회저빈진폭치정부상관(r=-0.352,P<0.05;r=-0.468,P<0.01).결론 여불반경조광증상적억욱증환자상비,반경조광증상적억욱증환자정식태뇌저빈진폭구유특이성,우기표현위쌍측광액회저빈진폭치증고,좌측구뇌급좌측사회저빈진폭치강저.해결과혹허가이작위HCL-32사사양성억욱증환자적생물학표기.
Objective To investigate the characteristics of hypomanic symptoms (HS) to the brain neural activity in the resting-state of the patients with major depressive disorder (MDD).Methods Twenty-three patients from 54 patients with MDD were defined as MDD with HS because their HCL-32 scores were higher than or equal to 12.The rest 31 patients were defined as MDD patients without HS because of the lower scores.After checking the match of the factors such as gender and age et al,there were 19 MDD patients with HS,19 patients without HS and 19 healthy controls in the final analysis.We analyzed the impact of HS to the regional brain function of the patients with MDD by amplitude of low-frequency fluctuation (ALFF).Results The patients with MDD had abnormal resting-state brain activity in a diffuse brain areas compared to healthy controls by the ALFF analysis.Compared to the patients without HS,the ALFF of the depressed MDD patients with HS were significantly higher in the bilateral orbitofrontal cortex (OFC;left OFC:MNI(x,y,z):-34,56,-10;t=5.26;right OFC:MNI(x,y,z):20,66,-2;t=493) and superior frontal cortex (SFC;left SFC:MNI(x,y,z):-4,66,8;t=4.12;right SFC:MNI(x,y,z):14,56,18,t=3.97,all P< 0.05);while lower in bilateral thalamus and left fusiform gyrus (P<0.05).Correlation analysis of ALFF at each voxel in the whole brain against the HCL-32 in the patients with MDD revealed significantly positive correlation in OFC (r=0.363,0.426,0.405,all P<0.05),negative correlation in left thalamus and left fusiform gyrus (r=-0.352,P<0.05;r=-0.468,P<0.01).Conclusions The study suggested that there were differences between the two subgroups patients with MDD defined by the HCL-32.Compared to the MDD without HS patients,MDD with HS patients showed increase ALFF in bilateral frontal cortex (especially the OFC),and decrease ALFF in left thalamus and left fusiform gyrus.These features may be regarded as the biomarker of the MDD patients who were positive to HCL-32 screening.