医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
18期
3304-3306
,共3页
刘颖(综述)%施敏%王美鑑(审校)
劉穎(綜述)%施敏%王美鑑(審校)
류영(종술)%시민%왕미감(심교)
终末期肾病%动脉钙化%发病机制%治疗策略
終末期腎病%動脈鈣化%髮病機製%治療策略
종말기신병%동맥개화%발병궤제%치료책략
End stage renal disease%Arterial calcification%Pathogenesis%Treatment strategies
动脉钙化的发展是导致终末期肾病( ESRD)患者心血管疾病高患病率和高病死率的重要因素。最新研究认为,钙磷沉积、血管平滑肌细胞向成骨细胞表型转化、微 RNAs的表达水平和代谢性酸中毒等均参与ESRD患者动脉钙化的发生、发展。 ESRD患者动脉钙化有效的治疗包括不含钙的磷酸盐结合剂、低剂量活性维生素D、拟钙剂、维生素K等。该文就 ESRD动脉钙化的研究进展予以综述。
動脈鈣化的髮展是導緻終末期腎病( ESRD)患者心血管疾病高患病率和高病死率的重要因素。最新研究認為,鈣燐沉積、血管平滑肌細胞嚮成骨細胞錶型轉化、微 RNAs的錶達水平和代謝性痠中毒等均參與ESRD患者動脈鈣化的髮生、髮展。 ESRD患者動脈鈣化有效的治療包括不含鈣的燐痠鹽結閤劑、低劑量活性維生素D、擬鈣劑、維生素K等。該文就 ESRD動脈鈣化的研究進展予以綜述。
동맥개화적발전시도치종말기신병( ESRD)환자심혈관질병고환병솔화고병사솔적중요인소。최신연구인위,개린침적、혈관평활기세포향성골세포표형전화、미 RNAs적표체수평화대사성산중독등균삼여ESRD환자동맥개화적발생、발전。 ESRD환자동맥개화유효적치료포괄불함개적린산염결합제、저제량활성유생소D、의개제、유생소K등。해문취 ESRD동맥개화적연구진전여이종술。
Patients with end stage renal disease(ESRD) having significant cardiovascular morbidity and mortality is in part due to the development of arterial calcification .New discoveries related to the passive pre-cipitation of calcium and phosphate crystals,the transdifferentiation of vascular smooth muscle cells to osteo-blasts,the expression level of miRNAs,and metabolic acidosis continue to reveal the mechanisms involved in the initiation and progression of arterial calcification in ESRD .The currently available treatment options for arterial calcification in ESRD include non-calcium containing phosphate binders ,low doses of active vitamin D,calcimimetic agent,vitamin K and so on.Here is to make a review of the research progress of arterial calci-fication in ESRD.