CAJ | 학술논문

化疗在晚期非小细胞肺癌治疗上的疗效已达一个平台，且毒性作用限制了化疗的进一步发展。随着对现代肿瘤分子生物学及基因水平的认识逐渐加深，靶向治疗以成为临床研究的重点，非小细胞肺癌术后给予分子靶向治疗已成为目前抗肿瘤研究的热点。靶向治疗是在细胞分子水平上，针对明确的致癌位点，设计相应的治疗药物，使药物进入体内特异性选择致癌位点结合而发生作用，从而最终使肿瘤细胞特异性死亡，正常组织细胞不受影响的一种治疗方法。常用的分子靶向治疗药物包括表皮生长因子受体抑制剂，抗血管生成药物，多靶点药物等。
화료재만기비소세포폐암치료상적료효이체일개평태，차독성작용한제료화료적진일보발전。수착대현대종류분자생물학급기인수평적인식축점가심，파향치료이성위림상연구적중점，비소세포폐암술후급여분자파향치료이성위목전항종류연구적열점。파향치료시재세포분자수평상，침대명학적치암위점，설계상응적치료약물，사약물진입체내특이성선택치암위점결합이발생작용，종이최종사종류세포특이성사망，정상조직세포불수영향적일충치료방법。상용적분자파향치료약물포괄표피생장인자수체억제제，항혈관생성약물，다파점약물등。
In the treatment of advanced non-small cell lung cancer,curative effect of chemotherapy has encountered the platform stage,and toxic effects restrict the further development of chemotherapy.As the molecular biology and gene level understanding of modern tumor is gradually deepened , targeted therapy has become the focus of the clinical research,and molecular targeted therapy after non-small cell lung cancer sur-gery has become the hotspot in the anti-tumor research.The targeted therapy is directed to a specific cancer sites on the cell molecular level,to design the corresponding drug,and make the drug to combine and interact with specific cancer sites in vivo, so as to eventually make specific death of tumor cells,without affecting nor-mal cells.The commonly used molecular targeted drugs include the epidermal growth factor receptor inhibi-tor,anti-angiogenesis drugs, multiple-target drugs etc.