CAJ | 학술논문

转化生长因子（ TGF）β1是TGF－β家族中的一个重要成员，近年来对 TGF－β1基因的研究发现，其基因多态性影响蛋白的转录，并与TGF－β1血浆水平相关，在多种疾病的发生、发展中起着重要的调节作用。 TGF－β1基因多态性在疾病的发展过程中具有复杂性，并可能具有人群特异性及疾病特异性，其与食管癌、胃癌，结直肠癌等消化道肿瘤的关系也在不断被研究，但研究结果不一。
전화생장인자（ TGF）β1시TGF－β가족중적일개중요성원，근년래대 TGF－β1기인적연구발현，기기인다태성영향단백적전록，병여TGF－β1혈장수평상관，재다충질병적발생、발전중기착중요적조절작용。 TGF－β1기인다태성재질병적발전과정중구유복잡성，병가능구유인군특이성급질병특이성，기여식관암、위암，결직장암등소화도종류적관계야재불단피연구，단연구결과불일。
The transforming growth factor( TGF) β1 is an important member in TGF-βfamily.In recent years, it is reported that there are gene polymorphisms of TGF-β1 ,and it affects genetic transcription, and is associated with the plasma levels of TGF-β1 ,so that it plays an important role in a variety of diseases.How-ever,its role in the disease process is complex,and it may be population specific and disease-specific.The relationship between gene polymorphisms of TGF-β1 and digestive tract cancer,such as esophageal cancer, gastric cancer, and colorectal cancer, are also studied constantly,though the results differ.