CAJ | 학술논문

目的：探讨初发白血病患者血常规和临床症状间的关系。方法选择2010年1月至2014年3月武汉大学人民医院确诊为初发白血病患者259例，应用全自动血液分析仪对259例初发白血病患者进行血常规分析，同时对临床工作中常见10种临床症状进行统计分析。结果慢性白血病的白细胞总数和血小板计数（PLT）明显高于急性白血病[86.4（19.4～207.8）×109／L 比9.4（3.3～44.4）×109／L，248（118～467）×109／L比34（18～84）×109／L]（P＜0.01）。体检发现、白细胞总数或PLT异常在慢性白血病临床症状中占第2位，为19.2％（15／78），在慢性淋巴细胞白血病中占第1位，为29.4％（5／17）。急性白血病的常见临床症状为乏力、发热感染、皮肤黏膜出血，骨关节疼痛”在急性淋巴细胞白血病临床症状中占第3位，为8.9％（5／56）。结论血常规项目的准确判读联合对常见临床症状的观察和询问能降低白血病的漏诊率，提高临床检验工作的准确性。
목적：탐토초발백혈병환자혈상규화림상증상간적관계。방법선택2010년1월지2014년3월무한대학인민의원학진위초발백혈병환자259례，응용전자동혈액분석의대259례초발백혈병환자진행혈상규분석，동시대림상공작중상견10충림상증상진행통계분석。결과만성백혈병적백세포총수화혈소판계수（PLT）명현고우급성백혈병[86.4（19.4～207.8）×109／L 비9.4（3.3～44.4）×109／L，248（118～467）×109／L비34（18～84）×109／L]（P＜0.01）。체검발현、백세포총수혹PLT이상재만성백혈병림상증상중점제2위，위19.2％（15／78），재만성림파세포백혈병중점제1위，위29.4％（5／17）。급성백혈병적상견림상증상위핍력、발열감염、피부점막출혈，골관절동통”재급성림파세포백혈병림상증상중점제3위，위8.9％（5／56）。결론혈상규항목적준학판독연합대상견림상증상적관찰화순문능강저백혈병적루진솔，제고림상검험공작적준학성。
Objective To explore relationship between blood routine examination results and clinical symptoms in the incipient leukemia patients.Methods A total of 259 cases with incipient leukemia admit-ted to Renmin Hospital of Wuhan University from Jan.2010 to Mar.2014 were selected,and the data of blood routine was analyzed by fully automatic hematology analyzer , and statistical analysis on 10 common clinical symptoms was conducted.Results Total white blood cells and platelet count of the chronic leukemia patients was higher than that of acute leukemia patients [86.4(19.4-207.8) ×109/L vs 9.4(3.3-44.4) × 109/L,248(118-467) ×109/L vs 34(18-84) ×109/L] (P <0.01).Health examination discovered the abnormal condition of the total white blood cells or platelet count was second highest [19.2%(15/78)] in the clinical symptoms of the chronic leukemia, and was first highest[29.4%(5/17)] in the clinical symp-toms of the chronic lymphocytic leukemia.The common clinical symptoms of acute leukemia were weakness, fever infection,and mucocutaneous hemorrhage and bone jont pain was third highest[8.9%(5/56)] in the clinical symptoms of acute lymphocytic leukemia .Conclusion Combination of blood routine examination results and clinical symptoms can reduce rate of missed diagnosis of leukemia,and improve the accuracy of the clinical examination.