CAJ | 학술논문

尽管应用醛固酮受体拮抗剂治疗心力衰竭的益处被多个大型临床随机对照试验所证实，并被临床治疗指南所推荐，但仅有一小部分适合应用醛固酮受体拮抗剂治疗的心力衰竭患者应用了这一药物，其部分原因是临床医师对醛固酮受体拮抗剂的主要不良反应———高钾血症和肾功能恶化的担心。该文对醛固酮受体拮抗剂在心力衰竭患者中应用的安全性做一综述，以提高人们对于这类药物的认识。
진관응용철고동수체길항제치료심력쇠갈적익처피다개대형림상수궤대조시험소증실，병피림상치료지남소추천，단부유일소부분괄합응용철고동수체길항제치료적심력쇠갈환자응용료저일약물，기부분원인시림상의사대철고동수체길항제적주요불량반응———고갑혈증화신공능악화적담심。해문대철고동수체길항제재심력쇠갈환자중응용적안전성주일종술，이제고인문대우저류약물적인식。
Although the benefits of aldosterone receptor antagonists have been confirmed with multiple randomized,controlled studies and recommended by heart failure guideline,only a fraction of the patients with heart failure who are eligible for the indications receive this medication .This maybe, in part, concerns of adverse events-hyperkalemia and deteriorated renal function known to occur with using of these drugs.Here is to make a review of the safety of aldosterone receptor antagonists in heart failure , in order to improve the knowledge of this kind of drugs.