CAJ | 학술논문

胰腺癌是一种恶性程度极高，诊断、治疗困难的消化道肿瘤，且其治疗手段局限，效果欠佳，严重威胁着人们的生命健康。姜黄素是从植物姜黄根茎中提取出的黄色粉末，能与多个靶分子相互作用，参与调控肿瘤生长和发展过程中的多条通路，是较为有效的抗肿瘤药物。该文通过国内外研究现状，介绍姜黄素及其类似物对肿瘤细胞，特别是胰腺癌细胞的抗癌作用及相关机制，阐述姜黄素在增强肿瘤细胞放射敏感性方面的作用。
이선암시일충악성정도겁고，진단、치료곤난적소화도종류，차기치료수단국한，효과흠가，엄중위협착인문적생명건강。강황소시종식물강황근경중제취출적황색분말，능여다개파분자상호작용，삼여조공종류생장화발전과정중적다조통로，시교위유효적항종류약물。해문통과국내외연구현상，개소강황소급기유사물대종류세포，특별시이선암세포적항암작용급상관궤제，천술강황소재증강종류세포방사민감성방면적작용。
Pancreatic cancer is a gastrointestinal tumor of high degree of malignancy ,with difficult diag-nosis and limited treatment,poor effect,so it is a serious threat to people′s life and health.Curcumin is yellow powder extracted from the rhizome of Curcuma longa ,which can interact with a plurality of target molecules, involved in multiple paths of the regulation of tumor growth and development ,thus is and effective anticancer drug.Here describes the research status of curcumin and its analogues on tumor cells,especially anticancer effect in pancreatic cancer cells and the mechanisms,to elucidate the role of curcumin in enhancing radiosen-sitivity of tumor cells.