医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
18期
3434-3435
,共2页
抑郁发作%主观幸福感%帕罗西汀%认知行为治疗
抑鬱髮作%主觀倖福感%帕囉西汀%認知行為治療
억욱발작%주관행복감%파라서정%인지행위치료
Depression episode%Subjective well-being feeling%Paroxetine%Cognitive-behavioral therapy
目的：比较帕罗西汀联合认知行为治疗与单用帕罗西汀治疗抑郁发作的临床疗效。方法选取2011年5月至2014年5月辽阳市第四人民医院的抑郁发作住院患者58例，采用单纯随机抽样方法分为研究组30例（帕罗西汀联合认知行为治疗）和对照组28例（单用帕罗西汀治疗），疗程12周。治疗前及治疗12周时采用汉密尔顿抑郁量表（ HAMD）、临床疗效总体量表（ CGI）及总体幸福量表（GWB）评定临床疗效。结果两组治疗后 HAMD 评分分别为（9.33±2.11）分和（17.18±1.74）分，CGI评分分别为（1.47±0.51）分和（3.29±0.76）分，两组较治疗前均显著下降（P ＜0.01）。研究组下降更为明显（P＜0.01）。 GWB评分分别为（77.20±1.43）分和（76.64±0.83）分，较治疗前均显著提升（P＜0.01），研究组提升更为明显（P＜0.01）。结论帕罗西汀联合认知行为治疗抑郁发作的效果较单用帕罗西汀好，前者可以更好地提升患者的主观幸福感。
目的：比較帕囉西汀聯閤認知行為治療與單用帕囉西汀治療抑鬱髮作的臨床療效。方法選取2011年5月至2014年5月遼暘市第四人民醫院的抑鬱髮作住院患者58例，採用單純隨機抽樣方法分為研究組30例（帕囉西汀聯閤認知行為治療）和對照組28例（單用帕囉西汀治療），療程12週。治療前及治療12週時採用漢密爾頓抑鬱量錶（ HAMD）、臨床療效總體量錶（ CGI）及總體倖福量錶（GWB）評定臨床療效。結果兩組治療後 HAMD 評分分彆為（9.33±2.11）分和（17.18±1.74）分，CGI評分分彆為（1.47±0.51）分和（3.29±0.76）分，兩組較治療前均顯著下降（P ＜0.01）。研究組下降更為明顯（P＜0.01）。 GWB評分分彆為（77.20±1.43）分和（76.64±0.83）分，較治療前均顯著提升（P＜0.01），研究組提升更為明顯（P＜0.01）。結論帕囉西汀聯閤認知行為治療抑鬱髮作的效果較單用帕囉西汀好，前者可以更好地提升患者的主觀倖福感。
목적：비교파라서정연합인지행위치료여단용파라서정치료억욱발작적림상료효。방법선취2011년5월지2014년5월료양시제사인민의원적억욱발작주원환자58례，채용단순수궤추양방법분위연구조30례（파라서정연합인지행위치료）화대조조28례（단용파라서정치료），료정12주。치료전급치료12주시채용한밀이돈억욱량표（ HAMD）、림상료효총체량표（ CGI）급총체행복량표（GWB）평정림상료효。결과량조치료후 HAMD 평분분별위（9.33±2.11）분화（17.18±1.74）분，CGI평분분별위（1.47±0.51）분화（3.29±0.76）분，량조교치료전균현저하강（P ＜0.01）。연구조하강경위명현（P＜0.01）。 GWB평분분별위（77.20±1.43）분화（76.64±0.83）분，교치료전균현저제승（P＜0.01），연구조제승경위명현（P＜0.01）。결론파라서정연합인지행위치료억욱발작적효과교단용파라서정호，전자가이경호지제승환자적주관행복감。
Objective To compare the clinical efficacy of paroxetine plus cognitive behavioral therapy and paroxetine monotherapy in the treatment of patients with depression .Methods Total of 58 patients (collected from Liaoyang NO.4 People′s Hospital from May 2011 to May 2014) with depressive disorder were randomly assigned to study group-paroxetine plus cognitive behavioral combination treatment group(n=30) and control group-paroxetine monotherapy group(n =28) for a 12-week trial.The clinical effect was assessed by Hamilton Depression rating scale(HAMD), clinical global impression(CGI) severity and Gen-eral Well-Being Schedule( GWB) at the beginning as well as the end of the 12-week treatment.Results After the treatment, the HAMD scores in the study group and the control group were (9.33 ±2.11) and (17.18 ±1.74) respectively.The CGI scores in the study group and the control group were (1.47 ±0.51) and (3.29 ±0.76) respectively,both groups showed a significant decrease compared with pretreatment(P<0.01),but the study group was more significant(P<0.01).The GWB score in the study group and the con-trol group were (77.20 ±1.43) and (76.64 ±0.83) respectively,both groups showed a significant improvement compared with pretreatment(P<0.01),but the study group was more significant(P<0.01). Conclusion Paroxetine plus cognitive behavioral therapy has better efficacy than paroxetine monotherapy in the treatment of depression, the combined therapy can better improve the patients′subjective well-being feeling.
