医学综述
醫學綜述
의학종술
Medical Recapitulate
2015年
18期
3386-3389
,共4页
急性心肌梗死%CD34细胞%心功能%左心室射血分数
急性心肌梗死%CD34細胞%心功能%左心室射血分數
급성심기경사%CD34세포%심공능%좌심실사혈분수
Acute myocardial infarction%CD34 cell%Heart function%Left ventricular ejection fractions
目的：探讨急性心肌梗死患者外周血CD34与心功能及冠状动脉狭窄的相关性和临床意义。方法选择2011年5月至2012年10月在内蒙古自治区人民医院心内科住院治疗的急性心肌梗死患者76例，根据Killip心功能分级分为KillipⅠ级组（29例）和KillipⅡ～Ⅳ级组（47例），同期选择30例正常体检者作为对照组。采用流式细胞仪检测3组受试者外周血CD34细胞数量，入院2周内急性心肌梗死患者行心脏彩色多普勒超声检查，测定左心室射血分数（LVEF），行冠状动脉造影， Gensini积分法计算冠状动脉狭窄程度。结果 KillipⅠ级组和 KillipⅡ～Ⅳ级组CD34细胞数分别为（681±267）个／μL、（919±310）个／μL，均高于对照组的（214±23）个／μL，差异有统计学意义（P ＜0.05），且KillipⅡ组CD34细胞数高于KillipⅠ级组（P＜0.05）。 KillipⅡ～Ⅳ级组Gensini积分显著高于KillipⅠ级组[（48±21）分比（30±12）分]，差异有统计学意义（P＜0.01）。 CD34细胞数与 LVEF呈负相关（r＝－0.468，P ＝0.000），与 Gensini 积分呈正相关（r＝0.301，P ＝0.008）。结论检测CD34细胞数量可判断急性心肌梗死患者的心功能和冠状动脉狭窄的程度，为临床判断预后提供依据。
目的：探討急性心肌梗死患者外週血CD34與心功能及冠狀動脈狹窄的相關性和臨床意義。方法選擇2011年5月至2012年10月在內矇古自治區人民醫院心內科住院治療的急性心肌梗死患者76例，根據Killip心功能分級分為KillipⅠ級組（29例）和KillipⅡ～Ⅳ級組（47例），同期選擇30例正常體檢者作為對照組。採用流式細胞儀檢測3組受試者外週血CD34細胞數量，入院2週內急性心肌梗死患者行心髒綵色多普勒超聲檢查，測定左心室射血分數（LVEF），行冠狀動脈造影， Gensini積分法計算冠狀動脈狹窄程度。結果 KillipⅠ級組和 KillipⅡ～Ⅳ級組CD34細胞數分彆為（681±267）箇／μL、（919±310）箇／μL，均高于對照組的（214±23）箇／μL，差異有統計學意義（P ＜0.05），且KillipⅡ組CD34細胞數高于KillipⅠ級組（P＜0.05）。 KillipⅡ～Ⅳ級組Gensini積分顯著高于KillipⅠ級組[（48±21）分比（30±12）分]，差異有統計學意義（P＜0.01）。 CD34細胞數與 LVEF呈負相關（r＝－0.468，P ＝0.000），與 Gensini 積分呈正相關（r＝0.301，P ＝0.008）。結論檢測CD34細胞數量可判斷急性心肌梗死患者的心功能和冠狀動脈狹窄的程度，為臨床判斷預後提供依據。
목적：탐토급성심기경사환자외주혈CD34여심공능급관상동맥협착적상관성화림상의의。방법선택2011년5월지2012년10월재내몽고자치구인민의원심내과주원치료적급성심기경사환자76례，근거Killip심공능분급분위KillipⅠ급조（29례）화KillipⅡ～Ⅳ급조（47례），동기선택30례정상체검자작위대조조。채용류식세포의검측3조수시자외주혈CD34세포수량，입원2주내급성심기경사환자행심장채색다보륵초성검사，측정좌심실사혈분수（LVEF），행관상동맥조영， Gensini적분법계산관상동맥협착정도。결과 KillipⅠ급조화 KillipⅡ～Ⅳ급조CD34세포수분별위（681±267）개／μL、（919±310）개／μL，균고우대조조적（214±23）개／μL，차이유통계학의의（P ＜0.05），차KillipⅡ조CD34세포수고우KillipⅠ급조（P＜0.05）。 KillipⅡ～Ⅳ급조Gensini적분현저고우KillipⅠ급조[（48±21）분비（30±12）분]，차이유통계학의의（P＜0.01）。 CD34세포수여 LVEF정부상관（r＝－0.468，P ＝0.000），여 Gensini 적분정정상관（r＝0.301，P ＝0.008）。결론검측CD34세포수량가판단급성심기경사환자적심공능화관상동맥협착적정도，위림상판단예후제공의거。
Objective To investigate the clinical significance and correlation between peripheral blood CD34 cell number and coronary stenosis of patients with acute myocardial infarction(AMI).Methods A total of 76 AMI patients of the Department of Cardiology of Inner Mongolia People′s Hospital from May 2011 to Oct.2012, were included in the study,and another 30 people for health examination during the same period were also included as control group.The 76 patients were divided into KillipⅠ group (29 cases) and KillipⅡ-Ⅳ group (47 cases) according to Killip heart function.The general information and history of diseases and electrocardiogram were collected.CD34 cell count in peripheral blood was determined by flow cytometry, cardiac color Doppler ultrasonography were completed within two weeks to determine left ventricular ejection fraction(LVEF).Coronary angiography was done.Gensini integration was used to calculate the degree of coronary stenosis.Results The number of CD34 cells of KillipⅠ group and KillipⅡ-Ⅳ group were (681 ± 267)count/μL and (919 ±310)count/μL,which were higher than the control group′s (214 ±23)count/μL with statistically significant difference(P <0.05),and the number of CD34 cells of KillipⅡ-Ⅳ group was higher than KillipⅠ group with statistically significant difference(P <0.05).Gensini integral of Killip Ⅱgroup was significantly higher than KillipⅠgroup [(48 ±21)scores vs (30 ±12)scores],the difference was statistically significant(P<0.01).The number of CD34 cells was negatively correlated with LVEF (r =-0.468, P=0.000), was positively correlated with Gensini integral(r=0.301,P=0.008).Conclusion The number of peripheral blood CD34 cell can be used to assess the cardiac function and coronary artery stenosis degree of AMI patients,provding reference for the prognosis judgment.
