CAJ | 학술논문

目的：探讨癌抗原125(CA125)联合人附睾蛋白4(HE-4)对卵巢癌术前诊断价值。方法选取2010年3月至2014年6月入院治疗的卵巢癌患者48例，卵巢良性肿瘤患者63例及健康体检者28例。收集血清标本，分别应用电化学发光法和酶联免疫吸附法检测血清中CA125和HE-4浓度。结果卵巢癌患者血清CA125及HE-4含量显著高于卵巢良性肿瘤患者和健康对照组(P ＜0.01)。 CA125与HE-4单独检测对卵巢癌的特异度分别为82.3%和92.3%， CA125联合HE-4检测特异度为93.1%； CA125与HE-4单独检测对卵巢癌的敏感度分别为68.6%和50.6%， CA125联合HE-4检测敏感度为94.3%(P＜0.01)。结论将HE-4结合传统卵巢癌检测血清标志物CA125检测，能有效提高卵巢癌的特异性和检出率，具有重要的临床意义。
목적：탐토암항원125(CA125)연합인부고단백4(HE-4)대란소암술전진단개치。방법선취2010년3월지2014년6월입원치료적란소암환자48례，란소량성종류환자63례급건강체검자28례。수집혈청표본，분별응용전화학발광법화매련면역흡부법검측혈청중CA125화HE-4농도。결과란소암환자혈청CA125급HE-4함량현저고우란소량성종류환자화건강대조조(P ＜0.01)。 CA125여HE-4단독검측대란소암적특이도분별위82.3%화92.3%， CA125연합HE-4검측특이도위93.1%； CA125여HE-4단독검측대란소암적민감도분별위68.6%화50.6%， CA125연합HE-4검측민감도위94.3%(P＜0.01)。결론장HE-4결합전통란소암검측혈청표지물CA125검측，능유효제고란소암적특이성화검출솔，구유중요적림상의의。
Objective To investigate the preoperative diagnosis value of cancer antigen 125 (CA125) combined with human epididymis protein 4 (HE-4) in ovarian carcinoma. Methods 48 patients with ovarian cancer, 63 patients with benign ovarian tumor and 28 healthy subjects admitted to our hospital from March 2010 to June 2014 were selected. The serum specimen was collected, the concentration of serum CA125 and serum HE-4 was detected by ECLIA and ELISA. Results The concentration of serum CA125 and serum HE-4 of ovarian carcinoma patients was higher than that of benign ovarian tumor patients and healthy cases (P <0.01). The specificity of single CA125 detection and single HE-4 detection was 82.3%, 92.3%respectively, lower than 93.1%of CA125+HE-4 detection;the sensitivity of single CA125 detection and single HE-4 detection was 68.6%, 50.6%respectively, lower than 94.3%of CA125+HE-4 detection (P<0.01). Conclusions CA125 combined with HE-4 in detecting ovarian carcinoma can effectively improve the specificity and sensitivity, which has important clinical significance.