化工进展
化工進展
화공진전
Chemical Industry and Engineering Progress
2015年
z1期
116-120
,共5页
贾义刚%刘维明%倪潇%黄和%胡燚
賈義剛%劉維明%倪瀟%黃和%鬍燚
가의강%류유명%예소%황화%호일
有机相%酶%转酯化%动力学拆分%左旋帕罗醇
有機相%酶%轉酯化%動力學拆分%左鏇帕囉醇
유궤상%매%전지화%동역학탁분%좌선파라순
organic media%enzyme%transesterification%kinetic resolution%trans-paroxol
研究了在有机相中脂肪酶催化转酯化反应动力学拆分左旋帕罗醇,考察了酶种类、溶剂、酰基供体、温度、底物与酰基供体摩尔比等因素对反应的影响。结果表明:以 Novozym 435为催化剂,在30℃下,以乙腈为反应溶剂,乙酸乙烯酯为酰基供体,底物浓度40mmol/L 及其与酰基供体摩尔比为1∶8时,反应8h 后,底物转化率为48.1%,ee s为53.3%,E 值为6.20。
研究瞭在有機相中脂肪酶催化轉酯化反應動力學拆分左鏇帕囉醇,攷察瞭酶種類、溶劑、酰基供體、溫度、底物與酰基供體摩爾比等因素對反應的影響。結果錶明:以 Novozym 435為催化劑,在30℃下,以乙腈為反應溶劑,乙痠乙烯酯為酰基供體,底物濃度40mmol/L 及其與酰基供體摩爾比為1∶8時,反應8h 後,底物轉化率為48.1%,ee s為53.3%,E 值為6.20。
연구료재유궤상중지방매최화전지화반응동역학탁분좌선파라순,고찰료매충류、용제、선기공체、온도、저물여선기공체마이비등인소대반응적영향。결과표명:이 Novozym 435위최화제,재30℃하,이을정위반응용제,을산을희지위선기공체,저물농도40mmol/L 급기여선기공체마이비위1∶8시,반응8h 후,저물전화솔위48.1%,ee s위53.3%,E 치위6.20。
The kinetic resolution of transesterification reaction of trans-paroxol catalyzed by lipase was studied in organic media.The influence factors including enzyme source,solvent,acyl donor, temperature,substrate and the molar ratio of substrate with acyl donor were researched.The optimal conditions were obtained as following:Acetonitrile as solvent, viny acetate as acyl donor,concentration of substrate of 40mmol/L,the molar ratio substrate with acyl donor of 1∶8 and reaction temperature 30℃.The conversion,the ees and the E value reached 48.1%,53.3%and 6.20 under the optimal conditions after 8h.