CAJ | 학술논문

与传统生物传感器相比，微纳米流体生物传感器在减少样品使用剂量，实现高通量、快速检测、特异性检测，以及简化实验操作等方面都显示出无可比拟的优越性。本文所涉及的微纳米的生物传感器大体上可以分成两大类：第一类是常规的微纳米流控生物传感器(简称微流控芯片)，通常以硅、玻璃以及高分子聚合物作为基材；第二类则是最近兴起的试纸条生物传感器，其基材为纸质。本文从以下几方面对当前微流体生物传感器的研究与应用进行总结：微流体生物传感器的基本理论，材料特征与制作工艺方面，以及在环境监测领域的典型性应用，最后对基于各种不同工艺技术制作的微流体生物传感器在技术方面的难点和应用上的局限性进行简要分析。
여전통생물전감기상비，미납미류체생물전감기재감소양품사용제량，실현고통량、쾌속검측、특이성검측，이급간화실험조작등방면도현시출무가비의적우월성。본문소섭급적미납미적생물전감기대체상가이분성량대류：제일류시상규적미납미류공생물전감기(간칭미류공심편)，통상이규、파리이급고분자취합물작위기재；제이류칙시최근흥기적시지조생물전감기，기기재위지질。본문종이하궤방면대당전미류체생물전감기적연구여응용진행총결：미류체생물전감기적기본이론，재료특정여제작공예방면，이급재배경감측영역적전형성응용，최후대기우각충불동공예기술제작적미류체생물전감기재기술방면적난점화응용상적국한성진행간요분석。
Compared to traditional biosensors,micro/nano-fluidic based biosensors show great advantages in reducing sample volume,rapid and specific detection,high throughput,and easy manipulation.These superiorities have paved the way for micro/nano-fluidic based biosensors to become real world products finally.The small scale biosensors are categorized into two broad classes here,which are the conventional micro/nano-fluidic based biosensors and microfluidic paper-based analytical devices (μPADs ) emerged recently.This chapter starts with a brief introduction of the current state-of-the-art micro/nano-fluidic based biosensors,followed by the relevant underlying theories,characterisation of materials,development of fabrication techniques and some typical applicationsin environmental monitoring.The limitations and perspectives of the biosensors based on different techniques are simply suggested.