中国临床医生杂志
中國臨床醫生雜誌
중국림상의생잡지
Chinese Journal for Clinicians
2015年
10期
20-23
,共4页
血液灌流%血液透析%微炎症%营养
血液灌流%血液透析%微炎癥%營養
혈액관류%혈액투석%미염증%영양
Hemoperfusion%Hemodialysis%Microinflammation%Nutrition
目的探讨血液灌流( HP)联合血液透析与单纯透析( HD)对维持性血液透析( MHD)患者微炎症状态和营养状况的影响。方法选取本院血液净化中心进行MHD的终末期肾病患者68例，按随机原则分为HP+HD组和单纯HD组各34例。 HP+HD组每周行HP串联HD治疗1次，单纯HD治疗2次，每周共3次；单纯HD组进行常规HD治疗，每周共3次，两组均连续治疗3个月。分别于治疗前和治疗3个月后采血，检测血超敏C反应蛋白( hs-CRP)、同型半胱氨酸( Hcy)、血红蛋白( Hb)、血清白蛋白( Alb)、前白蛋白( Pre-Alb)水平的变化。结果HP+HD组自身治疗前后相比及与HD组治疗后相比，血hs-CRP、Hcy均明显下降(P<0.05)，血Hb、Alb、Pre-Alb均明显上升(P<0.05)；HD组较治疗前血hs-CRP、Hcy及Hb、Alb、Pre-Alb均无明显变化(P>0.05)。结论HP联合HD进行血液净化治疗可有效清除中大分子炎症因子，明显改善MHD患者的微炎症状态及营养状况。
目的探討血液灌流( HP)聯閤血液透析與單純透析( HD)對維持性血液透析( MHD)患者微炎癥狀態和營養狀況的影響。方法選取本院血液淨化中心進行MHD的終末期腎病患者68例，按隨機原則分為HP+HD組和單純HD組各34例。 HP+HD組每週行HP串聯HD治療1次，單純HD治療2次，每週共3次；單純HD組進行常規HD治療，每週共3次，兩組均連續治療3箇月。分彆于治療前和治療3箇月後採血，檢測血超敏C反應蛋白( hs-CRP)、同型半胱氨痠( Hcy)、血紅蛋白( Hb)、血清白蛋白( Alb)、前白蛋白( Pre-Alb)水平的變化。結果HP+HD組自身治療前後相比及與HD組治療後相比，血hs-CRP、Hcy均明顯下降(P<0.05)，血Hb、Alb、Pre-Alb均明顯上升(P<0.05)；HD組較治療前血hs-CRP、Hcy及Hb、Alb、Pre-Alb均無明顯變化(P>0.05)。結論HP聯閤HD進行血液淨化治療可有效清除中大分子炎癥因子，明顯改善MHD患者的微炎癥狀態及營養狀況。
목적탐토혈액관류( HP)연합혈액투석여단순투석( HD)대유지성혈액투석( MHD)환자미염증상태화영양상황적영향。방법선취본원혈액정화중심진행MHD적종말기신병환자68례，안수궤원칙분위HP+HD조화단순HD조각34례。 HP+HD조매주행HP천련HD치료1차，단순HD치료2차，매주공3차；단순HD조진행상규HD치료，매주공3차，량조균련속치료3개월。분별우치료전화치료3개월후채혈，검측혈초민C반응단백( hs-CRP)、동형반광안산( Hcy)、혈홍단백( Hb)、혈청백단백( Alb)、전백단백( Pre-Alb)수평적변화。결과HP+HD조자신치료전후상비급여HD조치료후상비，혈hs-CRP、Hcy균명현하강(P<0.05)，혈Hb、Alb、Pre-Alb균명현상승(P<0.05)；HD조교치료전혈hs-CRP、Hcy급Hb、Alb、Pre-Alb균무명현변화(P>0.05)。결론HP연합HD진행혈액정화치료가유효청제중대분자염증인자，명현개선MHD환자적미염증상태급영양상황。
Objective To observe influence of hemoperfusion( HP) combining with hemodialysis( HD) on microinflam-mation and nutrition of patients with maintenance hemodialysis. Method Total 68 patients with maintenance hemodial-ysis admitted to blood purification center of Jishuitan Hospital in Beijing were stochastically divided into two different groups, including HP+HD group with 34 cases and pure HD group with 34 cases. HP+HD group took HP plus HD treatment in series order once a week and pure HD took place twice a week. Total treatment is 3 times per week. Pure HD group took conventional HD 3 times per week. The therapeutic course in both groups are consecutive, lasting for three months. The variance of blood high sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),hemoglobin (Hb), serum albumin(Alb) and pre-albumin(Pre-Alb) before and after three-month treatment were observed and analyzed respectively. Result The outcome from two groups were analyzed and compared after three-month treatment. HP+HD group in hs-CRP and Hcy decreased obviously(P<0. 05),and the condition of Hb, Alb and Pre-Alb were im-proved significantly(P<0. 05). HD group in hs-CRP,Hcy Hb, Alb and Pre-Alb did not indicate any variance. (P>0. 05). Conclusion HP combining with HD is an effective method to remove increased inflammation factors and to im-prove microinflammation and nutrition status of patients with maintenance hemodialysis.
