CAJ | 학술논문

Objective:To investigate the effects of propofol pretreatment on serum NSE and S100βprotein content in elderly patients undergoing laparoscopic surgery.Methods: A total of 60 elderly patients of scheduled for elective laparoscopic gastrointestinal surgery were randomly divided into 3 groups with 20 cases each: propofol pretreatment group (Group S1), propofol pretreatment group (Group S2) and observation group (Group C). Blood samples were respectively taken from internal jugular vein simultaneously before pneumoperitoneum (H1); pneumoperitoneum was established after 1 h (H2); pneumoperitoneum was terminated immediately (H3); pneumoperitoneum was terminated after 1 h (H4). Meanwhile, blood samples (0.5mL) was immediately taken from transradial artery and jugular veins bulb at 4 time-point (heparin anticoagulant and cut off the air), venous blood gas analysis, blood glucose, blood lactic acid, Serum NSE and S100β protein concentration were detected.Results:The concentration of serum NSE and S100βprotein in two groups of patients at H2-H4 was significantly higher than H1. The concentration of serum NSE and S100β protein at H3 and concentration of serum NSE at H4 were increased significantly than H2 in three groups. The concentration of NES and S100β protein at H4 was significantly lower than H3; The concentration of serum NSE and S100β protein have no statistical significance at difference time-point between 2 groups.Conclusion: The pneumoperitoneum can cause brain damage in elderly patients undergoing laparoscopic surgery and different dosage of pump injection of propofol has no obviously effect on this kind of damage.