CAJ | 학술논문

目的：探讨使用胰高血糖素样肽-1治疗2型糖尿病的临床疗效。方法选取太钢总医院2013年9月至2014年9月收治的2型糖尿病患者118例作为研究对象，回顾性分析其临床资料。按照治疗方式将其分为两组，对照组58例采用常规疗法，即二甲双胍缓释片与甘精胰岛素；观察组60例使用胰高血糖素样肽-1，即艾塞那肽，对比两组临床疗效及不良反应。结果观察组总有效率为90.0％，优于对照组（77.6％），两组比较差异有统计学意义（ P＜0.05）；对照组不良反应发生率为10.0％，观察组为8.0％，两组比较差异未见统计学意义（ P＞0.05）。结论使用胰高血糖素样肽-1治疗2型糖尿病效果明显，不良反应少，但是生物半衰期短，因此临床使用受限。
목적：탐토사용이고혈당소양태-1치료2형당뇨병적림상료효。방법선취태강총의원2013년9월지2014년9월수치적2형당뇨병환자118례작위연구대상，회고성분석기림상자료。안조치료방식장기분위량조，대조조58례채용상규요법，즉이갑쌍고완석편여감정이도소；관찰조60례사용이고혈당소양태-1，즉애새나태，대비량조림상료효급불량반응。결과관찰조총유효솔위90.0％，우우대조조（77.6％），량조비교차이유통계학의의（ P＜0.05）；대조조불량반응발생솔위10.0％，관찰조위8.0％，량조비교차이미견통계학의의（ P＞0.05）。결론사용이고혈당소양태-1치료2형당뇨병효과명현，불량반응소，단시생물반쇠기단，인차림상사용수한。
Objective To investigate the clinical efficacy of glucagon-like peptide-1 on type 2 diabetes.Methods Select 118 cases of type 2 diabetic in general hospital of Taigang from September 2013 to September 2014 as the study objects, the clinical data were retrospectively analyszed.According to the treatment methods, they were divided into two groups, 58 cases with conventional therapy as the control group, were given metformin sustained-release tablets and insulin glargine;in observation group, 60 cases were given glucagon-like peptide-1(exenatide), the clinical efficacy and adverse reactions were compared between the two groups.Results The total effective rate of observation group was 90.0%, which was higher than that in the control group(77.6%) , the difference was significant( P<0.05);the incidence of adverse reactions in the control group was 10.0%and 8.0%in the observation group, there was no significant difference between the two groups( P>0.05 ) .Conclusions The effect of glucagon-like peptide-1 on type 2 diabetes is obvious, has less adverse reactions, but the biological half-life is short, so the clinical use is limited.