CAJ | 학술논문

目的：了解老年阻塞性睡眠呼吸暂停综合征（ obstructive sleep apnea syndrome，OSAS）合并慢性心力衰竭（ chronic heart failure，CHF）的发生率，并探讨两者之间关系和临床特点。方法筛查1658例60岁以上离退休干部，收集其多导睡眠呼吸监测结果，分析其临床资料及血浆脑钠肽（ brain natriuretic peptide， BNP）结果。结果所有离退休干部中OSAS患病率为32．1％（531例），CHF患病率为6．76％（112例）。无OSAS、轻度OSAS、中度OSAS和重度OSAS中CHF患病率分别为5．4％、6．1％、10．0％、17．5％（ P＜0．05）；最低血氧饱和度与CHF的发生显著相关（ P＜0．05），且呼吸暂停低通气指数与血浆BNP水平呈正相关（ P＜0．05）。结论60岁以上老年人中OSAS的发生率较高，且CHF的发生率在OSAS患者中明显增加，随着OSAS的严重程度呈递增趋势；多元回归分析，OSAS是CHF的独立危险因素。
목적：료해노년조새성수면호흡잠정종합정（ obstructive sleep apnea syndrome，OSAS）합병만성심력쇠갈（ chronic heart failure，CHF）적발생솔，병탐토량자지간관계화림상특점。방법사사1658례60세이상리퇴휴간부，수집기다도수면호흡감측결과，분석기림상자료급혈장뇌납태（ brain natriuretic peptide， BNP）결과。결과소유리퇴휴간부중OSAS환병솔위32．1％（531례），CHF환병솔위6．76％（112례）。무OSAS、경도OSAS、중도OSAS화중도OSAS중CHF환병솔분별위5．4％、6．1％、10．0％、17．5％（ P＜0．05）；최저혈양포화도여CHF적발생현저상관（ P＜0．05），차호흡잠정저통기지수여혈장BNP수평정정상관（ P＜0．05）。결론60세이상노년인중OSAS적발생솔교고，차CHF적발생솔재OSAS환자중명현증가，수착OSAS적엄중정도정체증추세；다원회귀분석，OSAS시CHF적독립위험인소。
Objective To explore the incidence of obstructive sleep apnea syndrome ( OSAS) combined with chronic heart failure ( CHF) in elderly patients and discuss relations between OSAS and CHF.Methods One thousand six hundred and fifty-eight cadres aged over 60 years were screened.Polysomnography (PSG) results were collected.Clinical data and brain natriuretic peptide (BNP) level were analyzed.Results OSAS incidence was 32.1%(531 cases) in all retired ca-dres.CHF incidence was 6.76%( 112 cases) .CHF incidence in normal, slight OSAS, mild OSAS and severe OSAS group was 5.4%, 6.1%, 10.0%and 17.5%respectively ( P<0.05) .The lowest oxygen saturation were significantly associated with the occurrence of CHF ( P<0.05) , and apnea-hypopnea index and blood BNP levels were positively correlated ( P<0.05) .Conclusion The inci-dence of OSAS in elderly people aged over 60 were high.The incidence of CHF significantly in-creased in patients with OSAS, with an increasing trend related to severity of OSAS.Logistic regre-ssion analysis showed that OSAS was an independent risk factor for CHF.