CAJ | 학술논문

[目的] 探讨活体肝癌经高强度聚焦超声( HIFU)治疗前后实时超声造影( CEUS)定量参数的变化特点,及其与肿瘤微血管密度( MVD)的相关性. [方法] 选取30只新西兰大白兔制成VX2肝癌模型,随机分为对照组(15只,不作HIFU治疗)和治疗组(15只,作HIFU治疗). 行CEUS检查,获得并记录曲线增强上升斜率( AS)、开始增强时间( AT)、达峰时间( TTP)、峰值强度( PI)、曲线下面积( AUC) ,并与造影后通过免疫组织化学检查获得的MVD进行相关性分析. [结果] 治疗组AS、PI、AUC较对照组明显下降(P<0.05);MVD较对照组明显减少(P<0.05);AT、TTP较对照组明显延迟(P<0.05). CEUS定量参数中AS、PI、AUC分别和MVD呈正相关(P<0.05);AT、TTP分别和MVD呈负相关(P<0.05). [结论] 肝癌组织的CEUS定量参数与MVD具有高度的相关性,可反映肝癌组织微血管结构变化的情况并有助于判断HIFU对肝癌的疗效及预后.
[목적] 탐토활체간암경고강도취초초성( HIFU)치료전후실시초성조영( CEUS)정량삼수적변화특점,급기여종류미혈관밀도( MVD)적상관성. [방법] 선취30지신서란대백토제성VX2간암모형,수궤분위대조조(15지,불작HIFU치료)화치료조(15지,작HIFU치료). 행CEUS검사,획득병기록곡선증강상승사솔( AS)、개시증강시간( AT)、체봉시간( TTP)、봉치강도( PI)、곡선하면적( AUC) ,병여조영후통과면역조직화학검사획득적MVD진행상관성분석. [결과] 치료조AS、PI、AUC교대조조명현하강(P<0.05);MVD교대조조명현감소(P<0.05);AT、TTP교대조조명현연지(P<0.05). CEUS정량삼수중AS、PI、AUC분별화MVD정정상관(P<0.05);AT、TTP분별화MVD정부상관(P<0.05). [결론] 간암조직적CEUS정량삼수여MVD구유고도적상관성,가반영간암조직미혈관결구변화적정황병유조우판단HIFU대간암적료효급예후.
[ Objective] To explore the variation features of contrast enhanced ultrasound ( CEUS) quantitative parameters and its correlation with tumor microvessel density ( MVD ) , after the treatment of living liver cancer using high intensity focused ultrasound ( HIFU ) . [ Methods ] A group of 30 New Zealand white rabbits were made into VX2 liver cancer models, that were randomly divided into control group ( n =15, not HIFU treatment) and treatment group ( n =15, HIFU treatment).CEUS was performed, then obtaining ascending slope(AS),arrival time(AT),time-to-peak(TTP),peak intensity ( PI) ,area under curve ( AUC ) .And correlation analysis was performed with MVD obtained by immune histochemical method. [ Results ] Compared with those in the control group, AS, PI, AUC were significantly decreased in treatment group (P <0.05) and so was MVD (P <0.05).AT,TTP were significantly delayed than those in the control group (P<0.05).The AS, PI, AUC of CEUS quantitative parameters were positively correlated with MVD (P<0.05).The AT, TTP respectively showed a negative correlation with MVD ( P<0.05) . [ Conclusion] CEUS quantitative parameters of liver cancer tissue have high correlation with MVD.It can reflect the microvessel structure change of the liver cancer tissue and help to judge the curative effect and prognosis of HIFU for liver cancer.