CAJ | 학술논문

目的：探讨钙拮抗剂在心血管疾病治疗过程中的作用机制及其不良反应发生情况。方法随机选取霍州煤电集团总医院2011年9月至2013年12月收治的采用钙拮抗剂进行治疗的心血管疾病患者129例，对患者的病史资料进行回顾性分析。结果本研究60例患者使用钙拮抗剂后出现不良反应，不良反应发生率为46．5％，其中以头痛发生率最高（51．7％），其次为外周组织水肿和面部潮红。结论钙拮抗剂是常用的心血管疾病治疗药物，临床应用时，应根据患者具体病情，结合药物性质和个体差异制定合理的用药方案，尽量避免长期大剂量用药，以降低不良反应的发生率。
목적：탐토개길항제재심혈관질병치료과정중적작용궤제급기불량반응발생정황。방법수궤선취곽주매전집단총의원2011년9월지2013년12월수치적채용개길항제진행치료적심혈관질병환자129례，대환자적병사자료진행회고성분석。결과본연구60례환자사용개길항제후출현불량반응，불량반응발생솔위46．5％，기중이두통발생솔최고（51．7％），기차위외주조직수종화면부조홍。결론개길항제시상용적심혈관질병치료약물，림상응용시，응근거환자구체병정，결합약물성질화개체차이제정합리적용약방안，진량피면장기대제량용약，이강저불량반응적발생솔。
Objective To investigate the mechanism of calcium antagonists in the treatment of cardiovascular disease and its adverse reactions.Methods From September 2011 to December 2013, 129 patients with cardiovascular disease adoptted calcium antagonists for treatment were chosen, the clini-cal data were retrospectively analyzed.Results For this study, a total of 60 cases had adverse reac-tions after use of calcium antagonists, the incidence of adverse reactions was 46.5%, with the high-est incidence of headache(51.7%) , followed by peripheral tissue edema and facial flushing.Con-clusions Calcium antagonists are commonly used in the treatment of cardiovascular disease.In clinical applications, the patient should be based on the specific condition, combined with the nature and individ-ual differences to develop a reasonable drug regimen, try to avoid long-term large doses of medication to reduce the incidence of adverse reactions.