CAJ | 학술논문

Objective: To study the correlated relationship between the myostatin level and the obesity, insulin resistance of patients with polycystic ovary syndrome. Methods: Based on cross-sectional case-control study, 165 polycystic ovary syndrome patients were divided into obese group and no-obese group.At the same time, 142 healthy women were chosen as the control group. The level of fasting glucose, fasting insulin, HOMA-IR (the index of insulin resistance), BMI, waist circumference, waist-hip ratio and the level of sex hormone were determined and compared between the control group and non-obese PCOS group, between the obese and non-obese PCOS group. The correlation between MSTN and the indicator above was analyzed by regression analysis. Results:Compared with the control group, the MSTN level was significantly higher in the patients with PCOS(18.71±15.54 vs. 14.0±15.22, P=0.014), but there was no significant difference between non-obese PCOS group and the control group, excluding the obesity factor. The result of regression analysis showed that the MSTN level was significantly related to the waist circumference, waist-hip ratio, BMI and the testosterone level. After adjusting the BMI and testosterone, the mutivariate regression analysis showed that the MSTN level was significantly related to the PCOS present. And our study did not show the correlation between the MSTN level and the insulin resistance in PCOS patients, while the latter was closely related to the occurrence and progression of PCOS. Conclusion: The MSTN level is significantly related to waist circumference, waist-hip ratio, BMI and the testosterone level.And the MSTN level is also significantly related to the PCOS present.