CAJ | 학술논문

目的：研究成人与儿童紫癜性肾炎的临床病理特点及其预后情况。方法选择2011年7月至2014年7月80例HSPN患者的临床资料，全部患者采用肾活检进行检查，并给予临床分型与分级，收集并总结两组患者发病诱因。给予对症治疗，对全部患者进行随访，观察两组患者的预后。结果成人疾病有明显诱发因素的占45．0％，儿童占15．0％，成人患者肉眼血尿患者明显高于儿童（ P＜0．05）；成人高血压明显高于儿童患者（ P＜0．05）；成人肾功能不全明显高于儿童（P＜0．05）；儿童腹痛明显高于成人（P＜0．05）；儿童浮肿显高于成人（P＜0．05）；儿童关节痛明显高于成人（P＜0．05）。从临床分型与病理分级情况，儿童组患者Ⅱ级较多，Ⅴ～Ⅵ级相对较少，而成人患者Ⅴ～Ⅵ级占比较高；儿童组患者经治疗后，有效率为97．5％；成人患者有效率为90．0％，儿童高于成人，但有效性比较，差异未见统计学意义（P＞0．05）。结论儿童HSPN患者有明显诱因的高于成人患者，从临床分型与病理分级来看，HSPN患者中，儿童患者病情相对成人要轻，因此，儿童HSPN患者预后要好于成人。
목적：연구성인여인동자전성신염적림상병리특점급기예후정황。방법선택2011년7월지2014년7월80례HSPN환자적림상자료，전부환자채용신활검진행검사，병급여림상분형여분급，수집병총결량조환자발병유인。급여대증치료，대전부환자진행수방，관찰량조환자적예후。결과성인질병유명현유발인소적점45．0％，인동점15．0％，성인환자육안혈뇨환자명현고우인동（ P＜0．05）；성인고혈압명현고우인동환자（ P＜0．05）；성인신공능불전명현고우인동（P＜0．05）；인동복통명현고우성인（P＜0．05）；인동부종현고우성인（P＜0．05）；인동관절통명현고우성인（P＜0．05）。종림상분형여병리분급정황，인동조환자Ⅱ급교다，Ⅴ～Ⅵ급상대교소，이성인환자Ⅴ～Ⅵ급점비교고；인동조환자경치료후，유효솔위97．5％；성인환자유효솔위90．0％，인동고우성인，단유효성비교，차이미견통계학의의（P＞0．05）。결론인동HSPN환자유명현유인적고우성인환자，종림상분형여병리분급래간，HSPN환자중，인동환자병정상대성인요경，인차，인동HSPN환자예후요호우성인。
Objective To investigate the clinicopathological characteristics of adults and children Henoch-schon-lein purpura nephritis(HSPN) and prognosis.Methods From July 2011 to July 2014, the clinical data of 80 cases of HSPN were chosen, all patients had biopsy-rays, and clinical classification and grading was given, the predisposing factors were collected and summarized. The patients were given symptomatic treatment, all patients were followed up, the prognosis of the two groups were ob-served.Results Adult diseases with significant predisposing factors accounted for 45.0%, while children with significant predisposing factors accounted for 15.0%, the incidence of gross hematuria was significantly higher in adult patients than that in children (P<0.05);the incidence of hypertension was significantly higher in adult patients than that in children ( P<0.05 ); the incidence of kidney dysfunction was significantly higher in adult patients than that in children ( P <0.05);the incidence of abdominal pain was significantly higher in children than that in adult patients(P<0.05);the in-cidence of edema was significantly higher in children than that in adult patients(P<0.05);the incidence of joint pain was significantly higher in children than that in adult patients(P<0.05).From the clinical classification and pathological grad-ing situation, children with grade Ⅱwere more, children with gradeⅤ~Ⅵrelatively less, while adult patients with gradeⅤ-Ⅵwere more;the efficiency was 97.5%in children after treatment;the efficiency was 90.0%in adult patients after treatment, but there was no significant difference( P>0.05 ) .Conclusions Children with HSPN have significant incen-tives than adult patients, from clinical classification and pathological grading, pediatric patients were relative light, there-fore, the prognosis of children with HSPN is better than that of adults.