CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗的临床效果。方法选取2012年5月至2014年5月收治98例慢性阻塞性肺疾病急性加重期患者，随机分为特布他林治疗组（对照组）48例及糖皮质激素联合特布他林治疗组（观察组）50例，观察比较两组患者的临床效果。结果观察组治疗后临床总有效率为94％，对照组为77．1％，差异有统计学意义（P＜0．05）。两组治疗前动脉血氧分压（PaO2）、动脉血二氧化碳分压（ PaCO2）、pH值比较差异未见统计学意义（ P＞0．05），治疗均有改善；但观察组PaO2、PaCO2改善幅度优于对照组（P＜0．05），pH值比较差异未见统计学意义（P＞0．05）。结论慢性阻塞性肺疾病急性加重期采用糖皮质激素联合特布他林治疗，临床效果显著，具较高的安全性，对改善患者预后意义重大，值得临床广泛推广应用。
목적：탐토만성조새성폐질병급성가중기채용당피질격소연합특포타림치료적림상효과。방법선취2012년5월지2014년5월수치98례만성조새성폐질병급성가중기환자，수궤분위특포타림치료조（대조조）48례급당피질격소연합특포타림치료조（관찰조）50례，관찰비교량조환자적림상효과。결과관찰조치료후림상총유효솔위94％，대조조위77．1％，차이유통계학의의（P＜0．05）。량조치료전동맥혈양분압（PaO2）、동맥혈이양화탄분압（ PaCO2）、pH치비교차이미견통계학의의（ P＞0．05），치료균유개선；단관찰조PaO2、PaCO2개선폭도우우대조조（P＜0．05），pH치비교차이미견통계학의의（P＞0．05）。결론만성조새성폐질병급성가중기채용당피질격소연합특포타림치료，림상효과현저，구교고적안전성，대개선환자예후의의중대，치득림상엄범추엄응용。
Objective To investigate the curative effect of glucocorticoid combined with terbutaline on patients with acute exacerbation of chronic obstructive pulmonary disease( COPD) .Methods Ninrty-eight patients with acute ex-acerbation of COPD from May 2012 to May 2014 were selected, they were randomly divided into two groups: terbutaline treatment group(control group, n=48) and glucocorticoid combined with terbutaline treatment group(observation group, n=50), the effects of the two groups were observed and compared.Results After treatment, the clinical total effective rate was 94%in observation group and 77.1% in control group, the difference was significant(P<0.05).Before treat-ment, PaO2, PaCO2, pH value had no significant difference between the two groups(P>0.05), and they were all im-proved after treatment, the improvement of PaO2 , PaCO2 in observation group was better than that in control group( P<0.05), but the difference of pH value was not significant(P>0.05).Conclusions Glucocorticoid combined with ter-butaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease, the clinical effect is significant, with high security, can improve the prognosis of patients, so is worthy of wider application.