CAJ | 학술논문

目的评价调强放疗联合局部热疗对局部晚期胰腺癌的近期疗效.方法随机选取我院2012年6月至2014年12月收治的80例局部晚期胰腺癌患者,依据治疗方法将患者分为两组,即治疗组(n=40)和对照组(n=40).给予对照组患者单纯调强放射治疗,给予治疗组患者调强放疗联合局部热疗.比对近期治疗效果及不良反应情况.结果所有患者治疗后症状均有所缓解,其中治疗组患者的治疗有效率(RR)为47.50%,而对照组为35.00%(P=0.022);治疗组患者的疾病控制率(DCR)为70.00%.而对照组为42.50%(P=0.013).治疗后治疗组的CBR有效率为55.00%(22/40),对照组的CBR有效率为30.00%(12/40),两组CBR有效率比较,差异具有统计学意义(P=0.024);两组患者治疗后的毒性反应发生率大致相当,差异均无明显统计学意义(P>0.05).结论局部热疗联合调强放疗治疗晚期胰腺癌时能够明显缓解患者的症状,提高有效率和疾病控制率,也有效提高患者的临床受益反应有效率,且不影响患者的生存率及治疗后未增加患者的不良反应.
목적 평개조강방료연합국부열료대국부만기이선암적근기료효.방법 수궤선취아원2012년6월지2014년12월수치적80례국부만기이선암환자,의거치료방법 장환자분위량조,즉치료조(n=40)화대조조(n=40).급여대조조환자단순조강방사치료,급여치료조환자조강방료연합국부열료.비대근기치료효과급불량반응정황.결과 소유환자치료후증상균유소완해,기중치료조환자적치료유효솔(RR)위47.50%,이대조조위35.00%(P=0.022);치료조환자적질병공제솔(DCR)위70.00%.이대조조위42.50%(P=0.013).치료후치료조적CBR유효솔위55.00%(22/40),대조조적CBR유효솔위30.00%(12/40),량조CBR유효솔비교,차이구유통계학의의(P=0.024);량조환자치료후적독성반응발생솔대치상당,차이균무명현통계학의의(P>0.05).결론 국부열료연합조강방료치료만기이선암시능구명현완해환자적증상,제고유효솔화질병공제솔,야유효제고환자적림상수익반응유효솔,차불영향환자적생존솔급치료후미증가환자적불량반응.
Objective evaluation of intensity-modulated radiotherapy combined local heat treatment of locally advanced pancreatic cancer in the near future curative effect.Methods randomly selected from June 2012 to December 2012 treated 80 cases of patients with locally advanced pancreatic cancer, according to treatment method divided the patients into two groups, the treatment group (n = 40) and the control group (n = 40). Give control group patients with pure intensity-modulated radiation therapy, intensity modulated radiation therapy (imrt) treatment group patients' joint local heat treatment. Than the recent therapeutic effect and adverse reactions.Results all patients after treatment symptoms abated, the treatment group in the treatment of patients with efficient (RR) was 47.50%, and the control group was 35.00% (P = 0.022); Disease control rates (DCR) treatment group patients was 70.00%. While the control group was 42.50% (P = 0.013). Treatment group after treatment of CBR effective rate was 55.00% (22/40), the control of the CBR effective rate was 30.00% (12/40), two groups of CBR efficient comparison, difference have statistical significance (P = 0.024); Two groups of patients after treatment of toxic reaction rate roughly, differences were no significant statistical significance (P> 0.05). Intensity modulated radiation therapy (imrt) conclusions local heat treatment of advanced pancreatic cancer can obviously alleviate the patient's symptoms, improve the efficiency and disease control, and effectively improve the patient's clinical benefit response efficiently, and will not affect the survival and did not increase the patient's adverse reactions after treatment.