CAJ | 학술논문

目的：观察三维适形放疗联合同期多西紫杉醇联合顺铂、5－氟尿嘧啶联合顺铂两种化疗方案治疗中晚期食管癌临床疗效。方法选取临汾市第四人民医院收治的中晚期食管癌患者86例作为研究对象，经临床病理证实，均行三维适形放疗，采用随机对照表将患者分为DC组和DF组，各43例，DC组为多西紫杉醇联合顺铂化疗方案，DF组为5－氟尿嘧啶联合顺铂化疗方案，观察两组缓解率、不良反应等，随访2年，观察患者的病死率。结果 DC组治疗有效率为81．40％，与DF组（76．74％）比较差异未见统计学意义（ P＞0．05）。 DC组白细胞减少的发生率为69．77％，较DF组高，胃肠道反应的发生率为30．23％，较DF组低，差异有统计学意义（ P＜0．05）。 DC组病死率为44．19％，较DF组低，但差异未见统计学意义（ P＞0．05）。结论两种化疗联合同步放疗方案近期疗效差异未见统计学意义，但DC组胃肠道反应发生率相对较低，可提高患者的耐受性。
목적：관찰삼유괄형방료연합동기다서자삼순연합순박、5－불뇨밀정연합순박량충화료방안치료중만기식관암림상료효。방법선취림분시제사인민의원수치적중만기식관암환자86례작위연구대상，경림상병리증실，균행삼유괄형방료，채용수궤대조표장환자분위DC조화DF조，각43례，DC조위다서자삼순연합순박화료방안，DF조위5－불뇨밀정연합순박화료방안，관찰량조완해솔、불량반응등，수방2년，관찰환자적병사솔。결과 DC조치료유효솔위81．40％，여DF조（76．74％）비교차이미견통계학의의（ P＞0．05）。 DC조백세포감소적발생솔위69．77％，교DF조고，위장도반응적발생솔위30．23％，교DF조저，차이유통계학의의（ P＜0．05）。 DC조병사솔위44．19％，교DF조저，단차이미견통계학의의（ P＞0．05）。결론량충화료연합동보방료방안근기료효차이미견통계학의의，단DC조위장도반응발생솔상대교저，가제고환자적내수성。
Objective To observe the clinical efficacy of three dimensional conformal radiotherapy combined with concurrent docetaxel combined with cisplatin, 5-fluorouracil and cisplatin two chemotherapy regimen on esophageal carcino-ma.Methods Chosed 86 cases of advanced esophageal cancer patients treated in the fourth people’ s hospital of Linfen as the research objects, proved by pathology, they were performed in three dimensional conformal radiotherapy, the 86 cases of advanced esophageal cancer patients were divided into DC group and DF group with random comparison table methods, 43 cases in each group, DC group for the combination of docetaxel and cisplatin chemotherapy, DF group with 5-fluoroura-cil and cisplatin chemotherapy scheme, the response rate, toxicity of the two groups followed up for 2 years, and the fatality rate of patients was observed.Results In DC group, the effective rate ( 81.40%) compared with the DF group (76.74%), the difference was not significant(P>0.05).White blood cells reduce rate of DC group(69.77%)was high-er than that of DF group, the gastrointestinal tract incidence rate(30.23%) was lower than that of DF group, there were significant differences (P<0.05).The mortality(44.19%) in DC group was lower than that of DF group, but there was on significant difference(P>0.05).Conclusions No significant differences in curative effect between the two chemother-apy combined with concurrent radiotherapy plan, but gastrointestinal tract reaction rate is relatively lower in DC group, and can enhance the tolerance of patients.