CAJ | 학술논문

目的：本文主要从氟哌酸的合成路线出发，探讨氟哌酸合成工艺的优化方法。方法通过对氟哌酸的合成路线进行分析，探讨可以跟上时代脚步的新合成工艺。结果氟哌酸合成工艺的优化主要包括三种：缩哌嗪和乙基化合成新工艺、7-位氟取代合成新工艺以及硼螯合物合成新工艺。结论随着科学技术的不断进步和社会的迅速发展，医药技术的发展进程也在不断加快，氟哌酸作为第三代喹诺酮类抗菌药物，具有副作用小、和其他抗菌素无交叉耐药性、组织渗透性好、生物利用度高、抗菌谱广以及抗菌作用强等特点，特别是对于革兰阴性杆菌具有非常强的杀菌作用。再加上吸收快、服用方便，目前已经广泛应用与尿道炎、肾盂肾炎、扁桃体炎以及咽喉炎等的治疗中。
목적：본문주요종불고산적합성로선출발，탐토불고산합성공예적우화방법。방법통과대불고산적합성로선진행분석，탐토가이근상시대각보적신합성공예。결과불고산합성공예적우화주요포괄삼충：축고진화을기화합성신공예、7-위불취대합성신공예이급붕오합물합성신공예。결론수착과학기술적불단진보화사회적신속발전，의약기술적발전진정야재불단가쾌，불고산작위제삼대규낙동류항균약물，구유부작용소、화기타항균소무교차내약성、조직삼투성호、생물이용도고、항균보엄이급항균작용강등특점，특별시대우혁란음성간균구유비상강적살균작용。재가상흡수쾌、복용방편，목전이경엄범응용여뇨도염、신우신염、편도체염이급인후염등적치료중。
ObjectiveThis article mainly from the synthetic route of norfloxacin,norfloxacin synthesis process of optimization method are discussed.MethodsThrough the analysis of norfloxacin synthesis routes,explore the new synthetic process steps can keep up with the Times.ResultsNorfl oxacin synthesis process optimization mainly includes three types: piperazine and ethyl combined into new technology,7-a fluorinated synthetic new technology and new technology of boron chelate synthesis.ConclusionWith the constant progress of science and technology and the rapid development of the society,also in the development of medical technology advancement speeding up unceasingly,norfl oxacin class as the third generation quinolone antibacterial drugs,small side effects,and other antibiotics without cross resistance,good permeability,high bioavailability,wide antibacterial spectrum and antibacterial activity is strong wait for a characteristic,especially for gram negative bacilli have very strong sterilization effect.Combined with fast absorption,easy to take,at present,has been widely used and urethritis,py elonephritis,tonsillitis,and sore throat,and other treatment.