CAJ | 학술논문

Objective: To analyze the correlation between serum IL-6, IL-10, IL-6/IL-10, TNF-α, hsCRP level and athermanous plaque instability among Acute Coronary Syndrome (ACS) patients, as well as discuss its clinical predictive value. Method: 240 patients admitted into our hospital from August 2011 to July 2013 for coronary angiography (CAG) were chosen, among which 188 cases were diagnosed with ACS. Patients were divided into acute myocardial infarction (AMI) group (106 cases), unstable angina (UA) group (82 cases) and control group of 52 cases of negative patients according to diagnosis. Serum IL-6, IL-10, IL-6/IL-10, TNF-α and hsCRP level were tested by ELISA and analyzed statistically. Results: Serum IL-6, IL-10, IL-6/IL-10 and TNF-α levels in observation groups were significantly higher than those of control group (P<0.05). Positive correlations between IL-6 and hsCRP were observed in observation groups (r=0.385, P<0.05). There was positive correlation between IL-6 and TNF-α (r=0.259, P<0.05). Conclusions: A certain degree of correlation was observed between serum IL-6/IL-10, TNF-α, hsCRP and ACS symptoms among ACS patients, and it is valuable for the clinical prediction of athermanous plague instability.