中国实用医刊
中國實用醫刊
중국실용의간
Chinese Journal of Practical Medicine
2015年
22期
7-9
,共3页
慢性阻塞性肺疾病%多索茶碱%氨茶碱%气道重塑
慢性阻塞性肺疾病%多索茶堿%氨茶堿%氣道重塑
만성조새성폐질병%다색다감%안다감%기도중소
Chronic obstructive pulmonary disease%Doxofylline%Aminophylline%Airway re-modeling
目的：针对多索茶碱对慢性阻塞性肺疾病患者气道重塑与痰液、血清炎性指标的影响进行分析研究。方法随机选取2013年6月至2014年6月期间在盂县人民医院进行慢性阻塞性肺疾病治疗的患者80例作为研究对象，将其平均分为对照组和观察组，对照组患者实施氨茶碱治疗，观察组患者实施多索茶碱治疗。针对两组患者治疗前、治疗5 d后、治疗10 d后的血清气道重塑指标、痰液、血清炎性指标检测结果，进行对比分析。结果观察组治疗后5d、10d的血清气道重塑指标及痰液、血清炎性指标均显著低于对照组，并且观察组治疗后5d、10d的检测水平均明显地低于本组治疗前（P均＜0.05），差异均有统计学意义。结论在慢性阻塞性肺疾病患者的治疗中，多索茶碱可以有效改善患者的气道重塑，对患者的痰液、血清指标具有良好的作用，所以可以将其在临床治疗中进行推广应用。
目的：針對多索茶堿對慢性阻塞性肺疾病患者氣道重塑與痰液、血清炎性指標的影響進行分析研究。方法隨機選取2013年6月至2014年6月期間在盂縣人民醫院進行慢性阻塞性肺疾病治療的患者80例作為研究對象，將其平均分為對照組和觀察組，對照組患者實施氨茶堿治療，觀察組患者實施多索茶堿治療。針對兩組患者治療前、治療5 d後、治療10 d後的血清氣道重塑指標、痰液、血清炎性指標檢測結果，進行對比分析。結果觀察組治療後5d、10d的血清氣道重塑指標及痰液、血清炎性指標均顯著低于對照組，併且觀察組治療後5d、10d的檢測水平均明顯地低于本組治療前（P均＜0.05），差異均有統計學意義。結論在慢性阻塞性肺疾病患者的治療中，多索茶堿可以有效改善患者的氣道重塑，對患者的痰液、血清指標具有良好的作用，所以可以將其在臨床治療中進行推廣應用。
목적：침대다색다감대만성조새성폐질병환자기도중소여담액、혈청염성지표적영향진행분석연구。방법수궤선취2013년6월지2014년6월기간재우현인민의원진행만성조새성폐질병치료적환자80례작위연구대상，장기평균분위대조조화관찰조，대조조환자실시안다감치료，관찰조환자실시다색다감치료。침대량조환자치료전、치료5 d후、치료10 d후적혈청기도중소지표、담액、혈청염성지표검측결과，진행대비분석。결과관찰조치료후5d、10d적혈청기도중소지표급담액、혈청염성지표균현저저우대조조，병차관찰조치료후5d、10d적검측수평균명현지저우본조치료전（P균＜0.05），차이균유통계학의의。결론재만성조새성폐질병환자적치료중，다색다감가이유효개선환자적기도중소，대환자적담액、혈청지표구유량호적작용，소이가이장기재림상치료중진행추엄응용。
Objective To study the effect of doxofylline on the airway remodeling and sputum, serum inflammatory indexes of patients with chronic obstructive pulmonary disease.Methods Randomly selected 80 cases with chronic obstructive pulmonary in People’ s Hospital of Yuxian from June 2013 to June 2014 as the research objects, and averagely divided them into control group and observation group. Control group were treated with aminophylline, observation group were treated with doxofylline.The air-way remodeling indicators, sputum and serum inflammatory index test results of patients before treatment and at fifth and tenth day after treatment were compared and analyzed.Results The serum airway re-modeling and sputum, serum inflammatory indexes of observation group at fifth and tenth day after the treatment were all significantly lower than those of control group,and those of observation group at 5th and 10 th day after the treatment were obviously lower than those before the treatment ( all P<0.05 ) , there were all significant differences.Conclusions In the treatment of patients with chronic obstructive pulmonary disease, doxofylline can effectively improve the patient ’ s airway remodeling, and has good effect on sputum, serum index, so it is worthy of popularization and application in the clinical treatment.
