CAJ | 학술논문

目的：探讨生长抑素与前列地尔早期联合应用治疗急性重症胰腺炎的临床疗效。方法将我院收治的126例（2006年12月至2013年12月）重症急性重症胰腺炎患者随机分为两组：治疗组（66例）和对照组（60例）；治疗组在常规治疗基础上采用生长抑素及前列地尔联合用药，对照组予以常规治疗和生长抑素。结果治疗组有效率96.7%，对照组有效率86.7%，治疗组疗效明显高于对照组（P<0.05）；与对照治疗后相比，治疗组降低血、尿淀粉酶和C反应蛋白（CRP）的作用更明显（P<0.01）；治疗组的症状体征消失的时间、血淀粉酶和血钙恢复正常时间以及平均住院时间均短于对照组（P<0.05）。结论生长抑素联合前列地尔治疗急性重症胰腺炎疗效显著，值得临床推广应用。
목적：탐토생장억소여전렬지이조기연합응용치료급성중증이선염적림상료효。방법장아원수치적126례（2006년12월지2013년12월）중증급성중증이선염환자수궤분위량조：치료조（66례）화대조조（60례）；치료조재상규치료기출상채용생장억소급전렬지이연합용약，대조조여이상규치료화생장억소。결과치료조유효솔96.7%，대조조유효솔86.7%，치료조료효명현고우대조조（P<0.05）；여대조치료후상비，치료조강저혈、뇨정분매화C반응단백（CRP）적작용경명현（P<0.01）；치료조적증상체정소실적시간、혈정분매화혈개회복정상시간이급평균주원시간균단우대조조（P<0.05）。결론생장억소연합전렬지이치료급성중증이선염료효현저，치득림상추엄응용。
ObjectiveTo evaluate the therapeutic effect of Alprostadil combined therapy with somatostatin in treatments of severe acute pancreatitis. Method126 patients of severe acute pancreatitis treated with somatostatin in our hospital from December 2006 to December 2013 were analyzed retrospectively. The control group was treated with somatostatin treatment, and the treatment group was treated with somatostatin combined with Alprostadil. The clinical effect,related parameters were observed for control group and treatment group.ResultThe total effective rate of the treatment group and the control group was 96.7% and 86.7% respectively(P<0.05).Compared with control group control group, the decline range of the treatment group in blood and urine amylase (U/L) and CRP (mg/L) is obviously superior to the control group(P<0.01). There was a signiifcant difference in symptoms and signs disappeared ,blood amylase restore normal, blood calcium returned to normal, hospital stays in the two groups(P<0.05).ConclusionThe somatostatin combined with Alprostadil for treatment of severe acute pancreatitis is better than conventional somatostatin medical treat.