CAJ | 학술논문

目的：探讨心先安及氨茶碱联合对COPD合并心功能不全患者治疗的安全性及疗效。方法42例中重度COPD合并心功能不全患者随机分为心先安组、氨茶碱组及联合治疗组，三组基础治疗相同。分别使用心先安、氨茶碱、心先安联合氨茶碱同时治疗，疗程7d。观察患者喘息症状、肺部听诊哮鸣音情况和肺功能最大呼气流量（PEF）改善情况及不良反应。结果对症状改善、肺部听诊哮鸣音减少率、PEF改善率心先安及氨茶碱联合组均优于心先安或氨茶碱组。结论心先安及氨茶碱联合使用疗效增加，不良反应无明显增加，在COPD合并心功能不全患者中应用较为安全。
목적：탐토심선안급안다감연합대COPD합병심공능불전환자치료적안전성급료효。방법42례중중도COPD합병심공능불전환자수궤분위심선안조、안다감조급연합치료조，삼조기출치료상동。분별사용심선안、안다감、심선안연합안다감동시치료，료정7d。관찰환자천식증상、폐부은진효명음정황화폐공능최대호기류량（PEF）개선정황급불량반응。결과대증상개선、폐부은진효명음감소솔、PEF개선솔심선안급안다감연합조균우우심선안혹안다감조。결론심선안급안다감연합사용료효증가，불량반응무명현증가，재COPD합병심공능불전환자중응용교위안전。
ObjectiveTo evaluate the safety of McAMP combined with aminophylline in patients of COPD combined with heart failure.Methods42 cases were randomly divided into 3 groups, McAMP group, aminophylline group and McAMP combined with aminophylline group. The release of symptom, the wheezing sound in physical examination and improvement of PEF were observed.ResultsAdministration of McAMP combined with aminophylline were more effective than using McAMP or aminophylline only. The side effecte of McAMP combined with aminophylline was not more severe than McAMP or aminophylline only.ConclusionAdministration of McAMP combined with aminophylline was effective and safe in patients on COPD combined with heart failure.