CAJ | 학술논문

近来有文献报道复杂的细胞因子环境下，调节性T细胞（regulatory T cells, Tregs）可以转变为表型和功能上酷似Th17的新的T细胞亚群，即白细胞介素（IL）-17+Foxp3+T细胞。IL-17+Foxp3+T细胞分泌IL-17并表达维甲酸受体相关孤儿受体γt（RORγt），在免疫系统中表现出双重特性。IL-17+Foxp3+T细胞的发现为理解Tregs和Th17的关系提供了新的思路。本文重点介绍了IL-17+Foxp3+T细胞的表型特征、分化来源和多效性功能，并进一步总结了炎症性疾病和肿瘤微环境中IL-17+Foxp3+T细胞的作用。
근래유문헌보도복잡적세포인자배경하，조절성T세포（regulatory T cells, Tregs）가이전변위표형화공능상혹사Th17적신적T세포아군，즉백세포개소（IL）-17+Foxp3+T세포。IL-17+Foxp3+T세포분비IL-17병표체유갑산수체상관고인수체γt（RORγt），재면역계통중표현출쌍중특성。IL-17+Foxp3+T세포적발현위리해Tregs화Th17적관계제공료신적사로。본문중점개소료IL-17+Foxp3+T세포적표형특정、분화래원화다효성공능，병진일보총결료염증성질병화종류미배경중IL-17+Foxp3+T세포적작용。
Recently, it is reported that regulatory T cells (Tregs) can be reprogrammed into a novel population [interleu?kin (IL)-17+Foxp3+T cells] phenotypically and functionally resembling Th17 cells under complicated cytokine circumstanc?es. IL-17+Foxp3+T cells are characterized by production of IL-17 and expression of retinoic acid receptor related orphan re?ceptor (ROR)γt, demonstrating dual functions in immune response and providing novel insight into the interconnection be?tween Tregs and Th17 cells. In this review, we lay emphasis on the phenotype features, origination, differentiation and the pleiotropic functions of IL-17+Foxp3+T cells. Furthermore, we summarized the functions of IL-17+Foxp3+T cells in inflam?matory disease and tumor microenvironment.