CAJ | 학술논문

胆道闭锁(BA)是婴儿期引起梗阻性黄疸的主要病因之一，以肝内外胆管进行性炎症和纤维性梗阻为主要特征，导致胆汁淤积和肝纤维化及肝硬化。肝纤维化中最重要的是肝星状细胞(HSC)的活化，这一过程受到多种机制的调节，其中miRNA家族成员可通过调控靶基因的表达，进而作用于多种信号通路促进HSC的活化，在细胞外基质(ECM)的合成和降解中发挥调节作用。大量文献表明PI3K/Akt信号通路与肝纤维化的发生、发展密切相关，参与了活化HSC增殖、凋亡的调控，miRNA通过各种靶基因激活PI3K/Akt信号通路，进而激活HSC，促进肝纤维化的发展。本文就胆道闭锁肝纤维化相关的miRNA综述如下。
담도폐쇄(BA)시영인기인기경조성황달적주요병인지일，이간내외담관진행성염증화섬유성경조위주요특정，도치담즙어적화간섬유화급간경화。간섬유화중최중요적시간성상세포(HSC)적활화，저일과정수도다충궤제적조절，기중miRNA가족성원가통과조공파기인적표체，진이작용우다충신호통로촉진HSC적활화，재세포외기질(ECM)적합성화강해중발휘조절작용。대량문헌표명PI3K/Akt신호통로여간섬유화적발생、발전밀절상관，삼여료활화HSC증식、조망적조공，miRNA통과각충파기인격활PI3K/Akt신호통로，진이격활HSC，촉진간섬유화적발전。본문취담도폐쇄간섬유화상관적miRNA종술여하。
Biliary atresia (BA), an inflammatory sclerosing cholangiopathy, is the leading cause of cholestasis in infants. Pathologic features of BA include progressive inflammation and intrahepatic and extrahepatic bile duct fibrosis. BA is charac?terized by rapid liver fibrosis. The activation of hepatic stellate cell (HSC) is most important in liver fibrosis. Many mecha?nisms are involved in this process. miRNA can promote the activation of HSC through a variety of signaling pathways by regu?lating the expression of target gene, then playing a regulatory role in the synthesis and degradation of extracellular matrix (ECM). A lot of literatures show that PI3K/Akt is closely related to the occurrence and development of hepatic fibrosis. PI3K/Akt signaling pathway is involved in the activation of HSC proliferation and apoptosis. MiRNA activates PI 3K/Akt signaling pathway through various target genes, and then activates HSC to promote the development of liver fibrosis. In this paper, the miRNA related to biliary atresia of liver fibrosis is summarized.