中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
28期
133-135
,共3页
何国民%徐娟%蔡亚云%贲海祥%陈婷
何國民%徐娟%蔡亞雲%賁海祥%陳婷
하국민%서연%채아운%분해상%진정
多发性骨髓瘤%化疗%低剂量沙利度胺%临床效果
多髮性骨髓瘤%化療%低劑量沙利度胺%臨床效果
다발성골수류%화료%저제량사리도알%림상효과
Multiple myeloma%Chemotherapy%Low-dose thalidomide%Clinical effect
目的 研究和讨论应用低剂量沙利度胺结合常规化疗对多发性骨髓瘤患者进行治疗的临床疗效情况. 方法 随机抽选2007年1月—2014年12月以来,在该院血液科进行治疗的100例多发性骨髓瘤患者.按照入院就诊时间将他们划分成对照组和观察组两组(每组各50例),分别采用常规化疗以及低剂量沙利度胺结合常规化疗进行临床诊治,并观察、分析和统计两组患者的治疗情况和临床效果. 结果 统计学比较显示,两组患者经过治疗后,其血M蛋白、血红蛋白浓度以及骨髓浆细胞值较之治疗前均有明显好转,且观察组明显优于对照组;观察组患者的临床总有效率(82.0%)以及OS、PFS值均明显高于对照组患者(52.0%),组内及组间对比结果的差异具有统计学意义(P<0.05). 结论 采用低剂量沙利度胺结合常规化疗对多发性骨髓瘤患者进行诊治,其临床疗效显著,能够有效改善患者指标情况,提高临床治疗效果,延迟患者生存时间,因此,它是一种有效、安全、理想、科学的临床诊治方法.
目的 研究和討論應用低劑量沙利度胺結閤常規化療對多髮性骨髓瘤患者進行治療的臨床療效情況. 方法 隨機抽選2007年1月—2014年12月以來,在該院血液科進行治療的100例多髮性骨髓瘤患者.按照入院就診時間將他們劃分成對照組和觀察組兩組(每組各50例),分彆採用常規化療以及低劑量沙利度胺結閤常規化療進行臨床診治,併觀察、分析和統計兩組患者的治療情況和臨床效果. 結果 統計學比較顯示,兩組患者經過治療後,其血M蛋白、血紅蛋白濃度以及骨髓漿細胞值較之治療前均有明顯好轉,且觀察組明顯優于對照組;觀察組患者的臨床總有效率(82.0%)以及OS、PFS值均明顯高于對照組患者(52.0%),組內及組間對比結果的差異具有統計學意義(P<0.05). 結論 採用低劑量沙利度胺結閤常規化療對多髮性骨髓瘤患者進行診治,其臨床療效顯著,能夠有效改善患者指標情況,提高臨床治療效果,延遲患者生存時間,因此,它是一種有效、安全、理想、科學的臨床診治方法.
목적 연구화토론응용저제량사리도알결합상규화료대다발성골수류환자진행치료적림상료효정황. 방법 수궤추선2007년1월—2014년12월이래,재해원혈액과진행치료적100례다발성골수류환자.안조입원취진시간장타문화분성대조조화관찰조량조(매조각50례),분별채용상규화료이급저제량사리도알결합상규화료진행림상진치,병관찰、분석화통계량조환자적치료정황화림상효과. 결과 통계학비교현시,량조환자경과치료후,기혈M단백、혈홍단백농도이급골수장세포치교지치료전균유명현호전,차관찰조명현우우대조조;관찰조환자적림상총유효솔(82.0%)이급OS、PFS치균명현고우대조조환자(52.0%),조내급조간대비결과적차이구유통계학의의(P<0.05). 결론 채용저제량사리도알결합상규화료대다발성골수류환자진행진치,기림상료효현저,능구유효개선환자지표정황,제고림상치료효과,연지환자생존시간,인차,타시일충유효、안전、이상、과학적림상진치방법.
Objective To study and discuss the use of low-dose thalidomide in combination with conventional chemotherapy clini-cal efficacy in patients with multiple myeloma treatment. Methods A randomized lottery since January 2007 - December 2014, in hematology hospital for treatment of 100 cases of multiple myeloma patients. Visited the hospital in accordance with the time they divided into two groups control group and observation group (n=50 patients), respectively conventional chemotherapy and low-dose thalidomide in combination with conventional chemotherapy for clinical diagnosis and treatment, and to observe, analyze and sta-tistical groups of patients The treatment and clinical results. Results The statistical comparison shows that the two groups of pa-tients after treatment, the blood M protein, hemoglobin concentration, and the value of bone marrow plasma cells were significantly improved compared with before treatment, and the observation group than the control group;total clinical observation group of pa-tients The response rate (82.0%) and OS, PFS were significantly higher in patients (52.0%), comparison between the results of the group and the group differences obviously, were statistically significant (P<0.05). Conclusion The low dose of thalidomide in com-bination with conventional chemotherapy for treatment of multiple myeloma patients, the clinical effect is significant, can improve the index patient, improve clinical treatment, survival time delay, therefore, it is an effective , security, ideals, scientific clinical diagnosis and treatment.
