CAJ | 학술논문

目的：对静脉注射吸毒人群中HIV感染者与HIV／HCV混合感染者的疾病进展及死亡情况进行对比分析，探讨HIV／HCV混合感染对HIV感染者自然病程的影响。方法对2006—2014年间吸毒人群哨点监测报告的HIV单独感染者与HIV／HCV混合感染者进行回顾性研究，获取CD4＋T淋巴细胞计数数据，通过艾滋病综合防治信息系统获得HIV／AIDS死亡的相关数据，两组人群进行对比分析。结果175例HIV单独感染者首次CD4＋T淋巴细胞计数平均值为370个／μl，且小于200个／μl的为25．71％，月均CD4＋T 淋巴细胞计数自然变化速率为：－1．50个／μl，1年内病死率为18．18％，352例HIV／HCV混合感染者首次CD4＋T 淋巴细胞计数平均值为420个／μl，且小于200个／μl的为20．45％，月均CD4＋T 淋巴细胞计数自然变化速率为：－2．76个／μl，1年内病死率为32．14％，两组人群差异均有统计学意义（P＜0．05）。结论与HIV单独感染者相比，HIV／HCV混合感染者被发现时免疫状况尚可，但是其CD4＋T淋巴细胞计数下降速度较快，疾病进展快，死亡速度也较快。必须加快制定针对HIV／HCV混合感染者的防治策略。
목적：대정맥주사흡독인군중HIV감염자여HIV／HCV혼합감염자적질병진전급사망정황진행대비분석，탐토HIV／HCV혼합감염대HIV감염자자연병정적영향。방법대2006—2014년간흡독인군초점감측보고적HIV단독감염자여HIV／HCV혼합감염자진행회고성연구，획취CD4＋T림파세포계수수거，통과애자병종합방치신식계통획득HIV／AIDS사망적상관수거，량조인군진행대비분석。결과175례HIV단독감염자수차CD4＋T림파세포계수평균치위370개／μl，차소우200개／μl적위25．71％，월균CD4＋T 림파세포계수자연변화속솔위：－1．50개／μl，1년내병사솔위18．18％，352례HIV／HCV혼합감염자수차CD4＋T 림파세포계수평균치위420개／μl，차소우200개／μl적위20．45％，월균CD4＋T 림파세포계수자연변화속솔위：－2．76개／μl，1년내병사솔위32．14％，량조인군차이균유통계학의의（P＜0．05）。결론여HIV단독감염자상비，HIV／HCV혼합감염자피발현시면역상황상가，단시기CD4＋T림파세포계수하강속도교쾌，질병진전쾌，사망속도야교쾌。필수가쾌제정침대HIV／HCV혼합감염자적방치책략。
Objective To comparatively analyze the HIV disease progression and the death situa-tion between injecting drug users (IDUs) with HIV infection and those with HIV/HCV co-infection.Meth-ods The counts of CD4+T cells were collected through a retrospective study and the data about death situa-tion were collected with follow-up cards from 2006 to 2014 .A statistical analysis was conducted for the two groups .Results Among the 175 cases with HIV infection , the average value of primary CD 4+T cell counts was 370 cell/μl and 25.71%of them, primary CD4+T cell counts were less than 200 cell/μl.The average change rate of CD4+T cell counts was -1.50 cell/μl in month.The annual mortality rate was 18.18%. Among the 325 cases with HIV/HCV co-infection, the average value of primary CD4+T cell counts was 420 cell/μl and 20.45%of them, primary CD4+T cell counts were less than 200 cell/μl.The average change rate of CD4+T cell counts was -2.76 cell/μl in month.The annual mortality rate was 32.14%.The differ-ences between the groups were significant (P<0.05).Conclusion Compared with patients with HIV infec-tion, those with HIV/HCV co-infection showed significantly decreased CD 4+T cell counts , resulting in a faster disease progression and a faster death .It was urgent for the management department to work out HIV prevention and therapeutic measures .